Comparison of cocaine, lidocaine/xylometazoline and saline for intranasal analgesia - A blinded triple crossover study

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2023-506644-17-01

Enrollment

Registered

2024-05-13

Start date

2024-07-01

Completion date

2024-08-27

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasotracheal intubation

Brief summary

Self reported pain felt during the procedure reported on a visual analogue scale of 0-100.

Detailed description

Self reported pain felt after one minute of tolerating the nasal tube reported on a visual analogue scale of 0-100., Acoustic rhinometry measurement with the use of the RhinoScan SRE2000, Interacoustics A/S, Assens, Denmark., Video-evaluated assessment of the degree of vasoconstriction on the nasal mucosa., Saliva samples analyzed for cocaine’s main metabolite benzoylecgonine., Blood samples analyzed for cocaine.

Interventions

DRUG-

DRUGNatriumklorid isotonisk "SAD"

DRUGinjektionsvæske

DRUGopløsning

DRUGLidokain SAD injektionsvæske

DRUGZymelin ukonserveret

DRUGnæsespray

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Self reported pain felt during the procedure reported on a visual analogue scale of 0-100.	—

Secondary

Measure	Time frame
Self reported pain felt after one minute of tolerating the nasal tube reported on a visual analogue scale of 0-100., Acoustic rhinometry measurement with the use of the RhinoScan SRE2000, Interacoustics A/S, Assens, Denmark., Video-evaluated assessment of the degree of vasoconstriction on the nasal mucosa., Saliva samples analyzed for cocaine’s main metabolite benzoylecgonine., Blood samples analyzed for cocaine.	—

Measure

Time frame

—

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026