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A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Apalutamide in Subjects with High-risk, Localized or Locally Advanced Prostate Cancer Who are Candidates for Radical Prostatectomy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-506153-38-00
Acronym
56021927PCR3011
Enrollment
668
Registered
2023-10-03
Start date
2019-07-11
Completion date
Unknown
Last updated
2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High-risk localized or locally advanced prostate cancer

Brief summary

pCR rate (as defined in the pathology charter and assessed by a pathology blinded independent central review [BICR]), MFS based on conventional or PSMA PET imaging (defined as the time from randomization to the date of the first occurrence of radiographic distant metastasis on conventional [ie, CT/MRI and bone scan] or PSMA PET imaging evaluated by radiology BICR, pathologic finding of distant metastasis, or death from any cause, whichever occurs first).

Interventions

DRUG-
DRUGApalutamide - Film-coated tablet

Sponsors

Janssen - Cilag International
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
pCR rate (as defined in the pathology charter and assessed by a pathology blinded independent central review [BICR]), MFS based on conventional or PSMA PET imaging (defined as the time from randomization to the date of the first occurrence of radiographic distant metastasis on conventional [ie, CT/MRI and bone scan] or PSMA PET imaging evaluated by radiology BICR, pathologic finding of distant metastasis, or death from any cause, whichever occurs first).

Countries

Czechia, France, Germany, Italy, Netherlands, Poland, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026