Goal-directed Fluid Therapy during deep inferior epigastric perforator (DIEP) free flap breast reconstruction – a randomized controlled trial

Conditions

Arterial hypotension during deep inferior epigastric perforator (DIEP) free flap breast reconstruction

Brief summary

Total intraoperative fluid volume (from anaesthesia induction until completed skin closure)

Detailed description

cumulative perioperative fluid volume (intraoperative fluid volume + fluid administered in the intensive care unit (ICU) or post-anaesthesia care unit (PACU)), cumulative intraoperative norepinephrine dose (intraoperative and postoperative norepinephrine dose), peri- and postoperative blood lactate levels (hourly measurement during surgery, every four hours in the ICU until discharge), percentage of time SBP was above 100mmHg, postoperative free flap perfusion monitored by NIRS during ICU/ PACU stay, surgical complications (e.g. total or partial flap loss, venous flap congestion, hematoma) assessed at ICU/ PACU discharge and at hospital discharge, ICU/PACU length of stay (LOS) (hours)

Related papers

No related papers found yet.

Interventions

DRUGPlasma-Lyte® 148 (pH 7.4) solution for infusion

DRUGNORADRENALINE (NOREPINEPHRINE) 1 mg / ml Concentrate for solution for infusion

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Total intraoperative fluid volume (from anaesthesia induction until completed skin closure)	—

Secondary

Measure	Time frame
cumulative perioperative fluid volume (intraoperative fluid volume + fluid administered in the intensive care unit (ICU) or post-anaesthesia care unit (PACU)), cumulative intraoperative norepinephrine dose (intraoperative and postoperative norepinephrine dose), peri- and postoperative blood lactate levels (hourly measurement during surgery, every four hours in the ICU until discharge), percentage of time SBP was above 100mmHg, postoperative free flap perfusion monitored by NIRS during ICU/ PACU stay, surgical complications (e.g. total or partial flap loss, venous flap congestion, hematoma) assessed at ICU/ PACU discharge and at hospital discharge, ICU/PACU length of stay (LOS) (hours)	—

Measure

Time frame

cumulative perioperative fluid volume (intraoperative fluid volume + fluid administered in the intensive care unit (ICU) or post-anaesthesia care unit (PACU)), cumulative intraoperative norepinephrine dose (intraoperative and postoperative norepinephrine dose), peri- and postoperative blood lactate levels (hourly measurement during surgery, every four hours in the ICU until discharge), percentage of time SBP was above 100mmHg, postoperative free flap perfusion monitored by NIRS during ICU/ PACU stay, surgical complications (e.g. total or partial flap loss, venous flap congestion, hematoma) assessed at ICU/ PACU discharge and at hospital discharge, ICU/PACU length of stay (LOS) (hours)

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Countries

Belgium

Outcome results

None listed