Hypertonic LActaTe afTer cardiac arrEst: the LATTE trial

Conditions

post-anoxic brain injury, Coma, Cardiac arrest, Post cardiac arrest syndrome

Brief summary

Neuron specific enolase (NSE) plasmatic peak values at 48 hours after return of spontaneous circulation.

Detailed description

Cerebral performance category score of 1 and 1-2 at 90 days., ICU length of stay (days), Hospital length of stay (days)., Mortality during ICU stay, during hospital stay, at 90 days., Vasopressor equivalent dose during the first 48h after resuscitation., Seizures episodes during the first 24h, 48h and ICU stay., Peak plasmatic concentrations or neurofilament light chain (NFL) at 24, 48 and 72h., Peak plasmatic concentrations or glial fibrillary acid protein (GFAP) at 24, 48 and 72h, Peak plasmatic concentrations or Troponin I (TnI) at 24, 48 and 72h, Incidence, nature, and severity of adverse events graded according to National Cancer Institute - Common Terminology Criteria for Adverse Events.

Related papers

No related papers found yet.

Interventions

DRUGPlasmalyte A Viaflo

DRUGsolution pour perfusion

DRUGSODIO LATTATO MONICO 2 mEq/ml concentrato per soluzione per infusione

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Neuron specific enolase (NSE) plasmatic peak values at 48 hours after return of spontaneous circulation.	—

Secondary

Measure	Time frame
Cerebral performance category score of 1 and 1-2 at 90 days., ICU length of stay (days), Hospital length of stay (days)., Mortality during ICU stay, during hospital stay, at 90 days., Vasopressor equivalent dose during the first 48h after resuscitation., Seizures episodes during the first 24h, 48h and ICU stay., Peak plasmatic concentrations or neurofilament light chain (NFL) at 24, 48 and 72h., Peak plasmatic concentrations or glial fibrillary acid protein (GFAP) at 24, 48 and 72h, Peak plasmatic concentrations or Troponin I (TnI) at 24, 48 and 72h, Incidence, nature, and severity of adverse events graded according to National Cancer Institute - Common Terminology Criteria for Adverse Events.	—

Measure

Time frame

Cerebral performance category score of 1 and 1-2 at 90 days., ICU length of stay (days), Hospital length of stay (days)., Mortality during ICU stay, during hospital stay, at 90 days., Vasopressor equivalent dose during the first 48h after resuscitation., Seizures episodes during the first 24h, 48h and ICU stay., Peak plasmatic concentrations or neurofilament light chain (NFL) at 24, 48 and 72h., Peak plasmatic concentrations or glial fibrillary acid protein (GFAP) at 24, 48 and 72h, Peak plasmatic concentrations or Troponin I (TnI) at 24, 48 and 72h, Incidence, nature, and severity of adverse events graded according to National Cancer Institute - Common Terminology Criteria for Adverse Events.

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Countries

Belgium

Outcome results

None listed