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A Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of AVP-786 (deudextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) for the treatment of agitation in patients with dementia of the Alzheimer’s type

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-504990-19-00
Acronym
20-AVP-786-306
Enrollment
267
Registered
2024-05-14
Start date
2021-04-06
Completion date
2024-05-22
Last updated
2024-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Agitation in Patients With Dementia of the Alzheimer's Type

Brief summary

The primary efficacy endpoint is the change from baseline to the end of the efficacy period in the CMAI total score.

Detailed description

The key secondary efficacy variable is the change from baseline to end of efficacy period in the CGI-S score, as related to agitation. It will be analyzed by the same statistical methodology specified for the analysis of the primary efficacy variable. The procedure to control the overall type I error rate for this key secondary efficacy analysis will be described in the SAP.

Interventions

Sponsors

Otsuka Pharmaceutical Development & Commercialization Inc., Otsuka Pharmaceutical Development & Commercialization Inc.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The primary efficacy endpoint is the change from baseline to the end of the efficacy period in the CMAI total score.

Secondary

MeasureTime frame
The key secondary efficacy variable is the change from baseline to end of efficacy period in the CGI-S score, as related to agitation. It will be analyzed by the same statistical methodology specified for the analysis of the primary efficacy variable. The procedure to control the overall type I error rate for this key secondary efficacy analysis will be described in the SAP.

Countries

Bulgaria, Denmark, Estonia, Germany, Greece, Poland, Portugal

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026