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(22423 NIRVANA) A randomized, parallel-group treatment, Phase 2, double-blind pilot study to investigate the efficacy and safety of elinzanetant compared with placebo for treatment of sleep disturbances associated with menopause

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-504955-28-01
Acronym
22423
Enrollment
84
Registered
2024-03-07
Start date
2024-03-14
Completion date
2024-07-31
Last updated
2024-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep disturbances associated with menopause

Brief summary

Change from baseline in WASO at Week 4 as measured by PSG

Detailed description

Change from baseline in WASO at Week 12 as measured by PSG, Change from baseline in SE at Week 4 as measured by PSG, Change from baseline in SE at Week 12 as measured by PSG, Change from baseline in PROMIS SD SF 8b total score at Week 4, Change from baseline in PROMIS SD SF 8b total score at Week 12, Change from baseline in ISI total score at Week 4, Change from baseline in ISI total score at Week 12, TEAEs, Abnormal laboratory parameters

Interventions

DRUGplacebo of BAY 3427080

Sponsors

Bayer Consumer Care AG, Bayer AG
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Change from baseline in WASO at Week 4 as measured by PSG

Secondary

MeasureTime frame
Change from baseline in WASO at Week 12 as measured by PSG, Change from baseline in SE at Week 4 as measured by PSG, Change from baseline in SE at Week 12 as measured by PSG, Change from baseline in PROMIS SD SF 8b total score at Week 4, Change from baseline in PROMIS SD SF 8b total score at Week 12, Change from baseline in ISI total score at Week 4, Change from baseline in ISI total score at Week 12, TEAEs, Abnormal laboratory parameters

Countries

Austria, Belgium, Czechia, Germany, Netherlands, Poland, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026