Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis (ANTEIPA)

Bronchiectasis

PA-eradication rate 6 months after the start of antibiotic therapy targeting PA

Exacerbation assessment at each follow-up visit, with time (in days) between the start of antibiotic therapy against PA and first exacerbation, Exacerbation assessment at each follow-up visit, Quality-of-life and treatment burden assessment using questionnaires, Quality of Life-Bronchiectasis (QOL-B), Bronchiectasis Impact Measure (BIM), Treatment Burden Questionnaire (TBQ) (+ EQ-5D-5L questionnaire for the medico-economic analysis), Detection of PA at 3-month and 1 year, PA-recurrence in sputum (or lower respiratory tract sample, if clinically justified), with time (in days) between the start of antibiotic therapy against PA and first PA-recurrence, Analysis of PA (or other bacteria) susceptibility to ciprofloxacin, if growing on respiratory sample(s) performed between 3 months and 12 months, AE and serious AEs will be recorded during medical interviews and by self-report in the study booklet during the study, Compliance to treatment and AEs will be recorded during medical interviews and by self-report in the study booklet during the study treatment period, time (in days), Compliance to treatment will be recorded during medical interviews and by self-report in the study booklet during the study treatment period, time (in days), Compliance to treatment will be recorded during medical interviews and by self-report in the study booklet during the study treatment period, time (in days), Total cost in each group, total quality adjusted life years (QALYs) in each group, difference in costs /difference in QALYs

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