Treating severe brain-injured patients with apomorphine : a behavioural and neuroimaging study

Conditions

Disorder of Consciousness, severe brain injury

Brief summary

Change of diagnosis from baseline in Coma Recovery Scale - Revised (CRS-R)

Detailed description

Change of total score in Nociception Coma Scale - Revised (NCS-R), Changes in EEG spectral power within fixed bands or dynamic connectivity using median spectral connectivity and graph-theoretic topology metrics, Changes in the probabilty of consciousness using a multivariate EEG classifier based on a machine-learning approach using 120 EEG markers, Changes in quantification of PET signal using standardized uptake values of fluorodeoxyglucose, Changes in MRI functional connectivity using a seed-voxel approach, between regions of interest (here: striatum, globus pallidus interna, thalamus and prefrontal cortex) and the time course from all other brain voxels, Change in circadian rhythmicity using actimetry and body temperature variations, Change in the architecture of sleep cycles using night EEG, Change of score in Glasgow Outcome Scale - Extended (GOS-E), Change in diagnosis in Phone-adapted CRS-R

Related papers

No related papers found yet.

Interventions

DRUGSodium Chloride 0

DRUG9%

DRUGApomorphine hydrochloride 5 mg/ml

DRUGsolution for infusion

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Change of diagnosis from baseline in Coma Recovery Scale - Revised (CRS-R)	—

Secondary

Measure	Time frame
Change of total score in Nociception Coma Scale - Revised (NCS-R), Changes in EEG spectral power within fixed bands or dynamic connectivity using median spectral connectivity and graph-theoretic topology metrics, Changes in the probabilty of consciousness using a multivariate EEG classifier based on a machine-learning approach using 120 EEG markers, Changes in quantification of PET signal using standardized uptake values of fluorodeoxyglucose, Changes in MRI functional connectivity using a seed-voxel approach, between regions of interest (here: striatum, globus pallidus interna, thalamus and prefrontal cortex) and the time course from all other brain voxels, Change in circadian rhythmicity using actimetry and body temperature variations, Change in the architecture of sleep cycles using night EEG, Change of score in Glasgow Outcome Scale - Extended (GOS-E), Change in diagnosis in Phone-adapted CRS-R	—

Measure

Time frame

Change of total score in Nociception Coma Scale - Revised (NCS-R), Changes in EEG spectral power within fixed bands or dynamic connectivity using median spectral connectivity and graph-theoretic topology metrics, Changes in the probabilty of consciousness using a multivariate EEG classifier based on a machine-learning approach using 120 EEG markers, Changes in quantification of PET signal using standardized uptake values of fluorodeoxyglucose, Changes in MRI functional connectivity using a seed-voxel approach, between regions of interest (here: striatum, globus pallidus interna, thalamus and prefrontal cortex) and the time course from all other brain voxels, Change in circadian rhythmicity using actimetry and body temperature variations, Change in the architecture of sleep cycles using night EEG, Change of score in Glasgow Outcome Scale - Extended (GOS-E), Change in diagnosis in Phone-adapted CRS-R

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Countries

Belgium, Spain

Outcome results

None listed