Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients (COPD-LIVE)

Conditions

Chronic obstructive pulmonary disease

Brief summary

Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from inclusion to 4 months post- inclusion.

Detailed description

Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from 3 to 4 months post- inclusion., Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from 1 to 3 months post- inclusion., Changes in blood levels of pro-inflammatory cytokines from inclusion to 3- and 4-months post- inclusion, Changes in epigenetic markers of innate immune cells., Number of hospital admissions, number of COPD exacerbations, and mortality 12 months after inclusion, Change in MRC, CAT and self-reported health from baseline to 12 months post-enrolment.

Related papers

No related papers found yet.

Papers published before 2007-09-01 may not appear yet. Historical indexing is in progress.

Interventions

DRUGM-M-RvaxPro powder and solvent for suspension for injection Measles

DRUGmumps and rubella vaccine (live)

DRUGSALINE

DRUGBCG Vaccine "AJ Vaccines"

DRUGpulver og solvens til injektionsvæske

DRUGsuspension

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from inclusion to 4 months post- inclusion.	—

Secondary

Measure	Time frame
Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from 3 to 4 months post- inclusion., Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from 1 to 3 months post- inclusion., Changes in blood levels of pro-inflammatory cytokines from inclusion to 3- and 4-months post- inclusion, Changes in epigenetic markers of innate immune cells., Number of hospital admissions, number of COPD exacerbations, and mortality 12 months after inclusion, Change in MRC, CAT and self-reported health from baseline to 12 months post-enrolment.	—

Measure

Time frame

Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from 3 to 4 months post- inclusion., Innate immune training, detected as fold-changes in cytokine production capacity of innate immune cells for cytokines such as IL-1β, IL-6, IL-10, TNF-α and IFN-γ, following pro-inflammatory stimulation from 1 to 3 months post- inclusion., Changes in blood levels of pro-inflammatory cytokines from inclusion to 3- and 4-months post- inclusion, Changes in epigenetic markers of innate immune cells., Number of hospital admissions, number of COPD exacerbations, and mortality 12 months after inclusion, Change in MRC, CAT and self-reported health from baseline to 12 months post-enrolment.

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Countries

Denmark

Outcome results

None listed