LiBRA – Lithium treatment to prevent cognitive impairment after brain radiotherapy.

Brain tumor

Change in Processing Speed Index (PSI) test score (sub-test of WPPSI/WISC/WAIS) 2 years after the start of study treatment compared to baseline, before study treatment.

Changes in the following neuropsychological/other test scores: • Complete set of WPPSI-IV/WISC-V/WAIS-IV sub-tests and their associated indices: o Processing Speed Index (PSI) o Verbal Comprehension Index (VCI) o Visual Spatial Index (VSI) o Fluid Reasoning Index (FRI) o Working Memory Index (WMI), Changes in Grooved Pegboard (motor speed), Changes in Beery/Buktenica VMI (visual-motor integration), Changes in Conner´s CPT III (sustained attention), Changes in D-KEFS TMT, D-KEFS CWT, D-KEFS Verbal fluency (executive functions) o If age <8 years: Nepsy II: Inhibition, Verbal fluency, Changes in Nepsy Word list (memory), Changes in Pediatric Quality of Life (PedsQL) Generic Core Scale Standard, Multidimensional Fatigue Scale., Changes in UCLA Loneliness Rating Scale 3 (ULS-3), Changes in Strengths and Difficulties Questionnaire (SDQ), Changes in Behavior Rating Inventory of Executive Function (BRIEF), Changes in the following neuropsychological/other test scores: o Processing Speed Index (PSI) o Working Memory Index (WMI), Evaluation of volumetric measures (hippocampal, total gray matter and total white matter volume) and diffusion tensor imaging (DTI) indices (FA, MD, RD, AD) on brain MRI at 6 months, 1 year, 2 years, 5 years and 10 years after start of study treatment, compared to baseline.

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Denmark, Sweden