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A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients with Metastatic Non-Small Cell Lung Cancer (Morpheus-Lung)

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-504038-23-00
Acronym
BO39610
Enrollment
149
Registered
2024-06-27
Start date
2018-05-10
Completion date
2025-04-02
Last updated
2025-02-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic non-small cell lung cancer (NSCLC)

Brief summary

Stage 1 1. Objective response rate (ORR)

Detailed description

Stage 1 1. PFS, Stage 1 2. PFS at specific time points, Stage 1 3. OS, Stage 1 4. OS at specific time points, Stage 1 5. DOR, Stage 1 6. DCR, Stage 1 and 2 7. Incidence, nature, and severity of adverse events and laboratory abnormalities, with severity determined according to National Cancer Institute Common Terminology Criteria for Adverse Events, Version 4.0, Stage 1 and 2 8. Change from baseline in vital signs, electrocardiogram parameters and targeted clinical laboratory test results

Interventions

Sponsors

F. Hoffmann-La Roche AG
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Stage 1 1. Objective response rate (ORR)

Secondary

MeasureTime frame
Stage 1 1. PFS, Stage 1 2. PFS at specific time points, Stage 1 3. OS, Stage 1 4. OS at specific time points, Stage 1 5. DOR, Stage 1 6. DCR, Stage 1 and 2 7. Incidence, nature, and severity of adverse events and laboratory abnormalities, with severity determined according to National Cancer Institute Common Terminology Criteria for Adverse Events, Version 4.0, Stage 1 and 2 8. Change from baseline in vital signs, electrocardiogram parameters and targeted clinical laboratory test results

Countries

France, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026