AN INVESTIGATOR-INITIATED, PHASE 4, OPEN-LABEL, SINGLE-ARM, SINGLE-CENTER STUDY INVESTIGATING THE TISSUE-RESIDENT MEMORY T-CELLS AND DISEASE MEMORY IN PSORIASIS SKIN DURING GUSELKUMAB TREATMENT. THE GUSMEM STUDY.

Psoriasis vulgaris

Change in the protein expression using DSP in the microenvironment surrounding TRMs in the epidermis. The following markers in combination will be used to differentiate TRMs: CD3, CD4, CD8, CD103., Change in the number of TRMs in the epidermis and dermis between baseline and EOT using IHC. The following markers in combination will be used to differentiate cells: CD3, CD4, CD8, CD103.

Change in CD11c+ Dendritic cells over the study duration., Change in CD163+ Macrophages over the study duration., Change in Langerin+/CD207+ Langerhans-cells over the study duration., Change in Myeloperoxidase+ Neutrophils over the study duration., Change in CD4+/FOXP3+ single and double positive cells over the study duration., Change in CD103/RORγt single and double positive cells over the study duration., Change in CD3+, CD4+, CD8+, CD49a+, CD69+, and CD103+ multiple, or single positive cells over the study duration., Change in proliferation assessed using Ki67+ staining over the study duration., Change in epidermal thickness over the study duration.

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