Obesity and Heart Failure with reduced Ejection Fracition
Conditions
Brief summary
The primary endpoint is change in peak oxygen uptake per kg per min (Vo2max) at 52 weeks between groups.
Detailed description
• To compare the effect of weight loss on quality of life assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ). • To compare the effect of weight loss on the 6MWD • To compare the effect of weight loss on the end-systolic volume assessed by Cardiac MR • To compare the effect of weight loss on the change in biomarkers as high-sensitivity CRP and pro-BNP • Feasibility and safety of a modern weight loss program for weight lowering in high-risk symptomatic patients.
Interventions
Sponsors
Region Hovedstaden
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is change in peak oxygen uptake per kg per min (Vo2max) at 52 weeks between groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| • To compare the effect of weight loss on quality of life assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ). • To compare the effect of weight loss on the 6MWD • To compare the effect of weight loss on the end-systolic volume assessed by Cardiac MR • To compare the effect of weight loss on the change in biomarkers as high-sensitivity CRP and pro-BNP • Feasibility and safety of a modern weight loss program for weight lowering in high-risk symptomatic patients. | — |
Countries
Denmark
Outcome results
None listed