The effect of Desflurane versus Sevoflurane versus Propofol on postoperative Delirium in elderly patients undergoing moderate- to high-risk major abdominal surgery – a prospective, double-blinded, randomized, clinical trial RAPID II Trial

Conditions

Elderly patients undergoing moderate- to high-risk major non cardiac surgery

Brief summary

Incidence of postoperative delirium within the first five postoperative days between maintenance of anesthesia with desflurane, sevoflurane or propofol in elderly patients undergoing noncardiac surgery

Detailed description

Incidence of postoperative cognitive dysfunction, Incidence of long-term postoperative cognitive dysfunction, Incidence of postoperative nausea and vomiting (PONV) within the first two postoperative hours, Incidence of PONV from two hours after surgery until the fifth postoperative day, Administration of supplemental oxygen in PACU or ICU for SpO2 ≥ 93%., Intraoperative duration of mean arterial pressure <65mmHg and overall amount of intraoperatively administered catecholamines (including phenylephrine, norepinephrine, epinephrine, etilefrine, ephedrine), Length of stay in the ICU after surgery until hospital discharge, Number of days at home within the first 30 postoperative days

Alexander Taschner, Edith Fleischmann, Barbara Kabon, Barbara Sinner, Christine A. Eckhardt et al. (13 authors)

BMJ Open2024-11-012 citations

10.1136/bmjopen-2024-092611

Interventions

DRUGPropofol „Fresenius" 2 % mit MCT - Emulsion zur Injektion oder Infusion

DRUGSevorane – Inhalationsnarkotikum

DRUGSUPRANE - Inhalationsnarkotikum

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium within the first five postoperative days between maintenance of anesthesia with desflurane, sevoflurane or propofol in elderly patients undergoing noncardiac surgery	—

Secondary

Measure	Time frame
Incidence of postoperative cognitive dysfunction, Incidence of long-term postoperative cognitive dysfunction, Incidence of postoperative nausea and vomiting (PONV) within the first two postoperative hours, Incidence of PONV from two hours after surgery until the fifth postoperative day, Administration of supplemental oxygen in PACU or ICU for SpO2 ≥ 93%., Intraoperative duration of mean arterial pressure <65mmHg and overall amount of intraoperatively administered catecholamines (including phenylephrine, norepinephrine, epinephrine, etilefrine, ephedrine), Length of stay in the ICU after surgery until hospital discharge, Number of days at home within the first 30 postoperative days	—

Measure

Time frame

Incidence of postoperative cognitive dysfunction, Incidence of long-term postoperative cognitive dysfunction, Incidence of postoperative nausea and vomiting (PONV) within the first two postoperative hours, Incidence of PONV from two hours after surgery until the fifth postoperative day, Administration of supplemental oxygen in PACU or ICU for SpO2 ≥ 93%., Intraoperative duration of mean arterial pressure <65mmHg and overall amount of intraoperatively administered catecholamines (including phenylephrine, norepinephrine, epinephrine, etilefrine, ephedrine), Length of stay in the ICU after surgery until hospital discharge, Number of days at home within the first 30 postoperative days

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Countries

Austria

Outcome results

None listed