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Palliation of Dyspnea and Cough using Morphine in patients with Fibrotic Interstitial Lung Disease

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-503700-81-00
Acronym
Morpheus
Enrollment
110
Registered
2024-03-11
Start date
2024-08-23
Completion date
Unknown
Last updated
2024-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fibrotic Interstitial Lung Disease

Brief summary

The change in average VAS score for dyspnea the last 24-hours (baseline) measured over a week and after 4 weeks treatment with morphine.

Detailed description

Change in walking distance during 6-minute walk test from baseline to follow-up after 4 weeks of treatment, Change in level of desaturation at 6-minute walk test from baseline to follow-up after 4 weeks of treatment, Change in BORG dyspnea scale at 6-minute walk test from baseline to follow-up after 4 weeks of treatment, Change in questionnaire (VAS for tough, Leicester Cough Questionnaire, King's Brief Lung Disease Questionnaire, COPD assessment Score) from baseline to follow-up after 4 weeks of treatment

Interventions

DRUGMalfin
DRUGContalgin
DRUGMST CONTINUS 5 mg prolonged-release tablets
DRUGPLACEBO

Sponsors

Aarhus University Hospital
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The change in average VAS score for dyspnea the last 24-hours (baseline) measured over a week and after 4 weeks treatment with morphine.

Secondary

MeasureTime frame
Change in walking distance during 6-minute walk test from baseline to follow-up after 4 weeks of treatment, Change in level of desaturation at 6-minute walk test from baseline to follow-up after 4 weeks of treatment, Change in BORG dyspnea scale at 6-minute walk test from baseline to follow-up after 4 weeks of treatment, Change in questionnaire (VAS for tough, Leicester Cough Questionnaire, King's Brief Lung Disease Questionnaire, COPD assessment Score) from baseline to follow-up after 4 weeks of treatment

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026