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A prospective, randomized, double-blind, placebo-controlled, two-stage, multicenter study with an open-label extension period to investigate the efficacy and safety of NT 201 in the treatment of lower limb spasticity in children and adolescents with cerebral palsy

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-503420-19-00
Acronym
M602011072
Enrollment
25
Registered
2024-05-06
Start date
2022-10-12
Completion date
2025-03-04
Last updated
2024-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric lower limb (LL) spasticity (SP) caused by cerebral palsy (CP)

Brief summary

Change in derived modified Ashworth Scale (MAS) score of plantar flexors from baseline at control visits at week 4 and week 6

Detailed description

Response in derived MAS score of plantar flexors at control visits at week 4 or week 6 with response defined as improvement of at least 1 point on the derived MAS score as compared to study baseline, GICS-PF score at control visits at week 4 and week 6 by investigator, GAS T-score at control visits at week 4 and week 6

Interventions

DRUGXEOMIN 200 V pulveris injekciju šķīduma pagatavošanai
DRUGXEOMIN

Sponsors

Merz Pharmaceuticals GmbH
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
0 Years to 17 Years

Design outcomes

Primary

MeasureTime frame
Change in derived modified Ashworth Scale (MAS) score of plantar flexors from baseline at control visits at week 4 and week 6

Secondary

MeasureTime frame
Response in derived MAS score of plantar flexors at control visits at week 4 or week 6 with response defined as improvement of at least 1 point on the derived MAS score as compared to study baseline, GICS-PF score at control visits at week 4 and week 6 by investigator, GAS T-score at control visits at week 4 and week 6

Countries

Latvia, Poland

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026