Anticoagulant Therapy in patients with atrial fibrillation after surgical Left Atrial Appendage Closure: a randomized non-inferiority trial (the ATLAAC trial)

Conditions

Atrial fibrillation

Brief summary

Stroke, peripheral embolisms and major bleeding events (composite endpoint)

Detailed description

Ischemic stroke, Hemorrhagic stroke, Severity of stroke according to Scandinavian Stroke Scale, Transient ischemic attack, Systemic embolism, All-cause stroke, All-cause mortality, Cardiovascular mortality, All types of bleeding leading to hospital contact, Blood transfusions, Myocardial infarction, Deep venous thrombosis, Pulmonary embolism, Length of the residual stump of the LAA, Volume of the residual stump of the LAA, Presence of contrast leakage across the closure line when relevant, Presence of thrombi in the LAA or the left atrium, Health-related quality of life scores

Gosvig K, Goller J, Hansson NH, Brandes A, Modrau I, Rasmussen LF, Eskesen K, Jensen AKG, Belley-Côté E, Whitlock R, Riber LPS.

2025-04-151 citations

10.1016/j.ahj.2025.04.015

Interventions

DRUGDABIGATRAN

DRUGWARFARIN SODIUM

DRUGEDOXABAN

DRUGAPIXABAN

DRUGRIVAROXABAN

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Stroke, peripheral embolisms and major bleeding events (composite endpoint)	—

Secondary

Measure	Time frame
Ischemic stroke, Hemorrhagic stroke, Severity of stroke according to Scandinavian Stroke Scale, Transient ischemic attack, Systemic embolism, All-cause stroke, All-cause mortality, Cardiovascular mortality, All types of bleeding leading to hospital contact, Blood transfusions, Myocardial infarction, Deep venous thrombosis, Pulmonary embolism, Length of the residual stump of the LAA, Volume of the residual stump of the LAA, Presence of contrast leakage across the closure line when relevant, Presence of thrombi in the LAA or the left atrium, Health-related quality of life scores	—

Measure

Time frame

Ischemic stroke, Hemorrhagic stroke, Severity of stroke according to Scandinavian Stroke Scale, Transient ischemic attack, Systemic embolism, All-cause stroke, All-cause mortality, Cardiovascular mortality, All types of bleeding leading to hospital contact, Blood transfusions, Myocardial infarction, Deep venous thrombosis, Pulmonary embolism, Length of the residual stump of the LAA, Volume of the residual stump of the LAA, Presence of contrast leakage across the closure line when relevant, Presence of thrombi in the LAA or the left atrium, Health-related quality of life scores

—

Countries

Denmark, Sweden

Outcome results

None listed