Skip to content

A Phase IIa, Open Label Study to Evaluate the Safety of Afamelanotide in Patients with Early Parkinson's Disease

Status
Withdrawn
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2022-502207-30-00
Acronym
CUV901
Enrollment
10
Registered
2023-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Brief summary

Assessment of Treatment Emergent Adverse Events including clinically significant changes in laboratory results.

Detailed description

Changes in α-synuclein levels in plasma from baseline (Day 1) to Day 56±2, Changes in inflammation biomarker in plasma from baseline (Day 1) to Day 56±2, Changes in cognition from baseline (Day 1) to Day 56±2, Changes in the NM in the MRI series from screening to Day 56±2, Changes in clinical improvement baseline (Day 1) to Day 56±2

Interventions

Sponsors

Clinuvel Europe Limited
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Assessment of Treatment Emergent Adverse Events including clinically significant changes in laboratory results.

Secondary

MeasureTime frame
Changes in α-synuclein levels in plasma from baseline (Day 1) to Day 56±2, Changes in inflammation biomarker in plasma from baseline (Day 1) to Day 56±2, Changes in cognition from baseline (Day 1) to Day 56±2, Changes in the NM in the MRI series from screening to Day 56±2, Changes in clinical improvement baseline (Day 1) to Day 56±2

Countries

Italy

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026