Healthy volunteers
Conditions
Brief summary
Percentage of (polysaccharide-specific) germinal centre B cells in lymph node aspirates, as determined by spectral flow cytometry
Detailed description
Kinetics of the proportion of T follicular helper cells in lymph node aspirates, Dynamics in B cell and T cell phenotype in lymph node aspirates, including immunoglobulin class switching and activation/differentiation markers, Deep immunophenotyping of B cells and T cells in peripheral blood by spectral flow cytometry, Timing of seroconversion in peripheral blood, Cytokine concentration in peripheral blood and lymph node aspirate
Interventions
Sponsors
Leiden University Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of (polysaccharide-specific) germinal centre B cells in lymph node aspirates, as determined by spectral flow cytometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Kinetics of the proportion of T follicular helper cells in lymph node aspirates, Dynamics in B cell and T cell phenotype in lymph node aspirates, including immunoglobulin class switching and activation/differentiation markers, Deep immunophenotyping of B cells and T cells in peripheral blood by spectral flow cytometry, Timing of seroconversion in peripheral blood, Cytokine concentration in peripheral blood and lymph node aspirate | — |
Countries
Netherlands
Outcome results
None listed