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A Phase 3, Multicenter, Double Blind, Active-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral Ozanimod Compared to Oral Fingolimod in Children and Adolescents with Relapsing Remitting Multiple Sclerosis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2022-501332-42-00
Acronym
IM047-050
Enrollment
38
Registered
2024-09-11
Start date
2025-02-26
Completion date
Unknown
Last updated
2026-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Relapsing Remitting Multiple Sclerosis

Brief summary

Core phase: To assess rate of Multiple Sclerosis (MS) relapse over 2 years

Detailed description

Core and Extension Phase: proportion of the participants who have worsening or improving RRMS, Core and Extension Phase: occurrence of adverse events (type, severity and relationship to the study drug), Core and Extension Phase: early study discontinuation, Core and Extension Phase: measurements of the amount of ozanimod in a participant’s body

Interventions

DRUGFINGOLIMOD
DRUGOzanimod HCl 0.23 mg
DRUGOzanimod HCl 1 mg
DRUGOzanimod HCl 0.0575 mg
DRUGOzanimod HCl 0.25 mg
DRUGOzanimod HCl
DRUGFingolimod 0.25 mg capsule
DRUGFingolimod 0.5 mg capsule

Sponsors

Bristol-Myers Squibb Services Unlimited Company
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
0 Years to 17 Years

Design outcomes

Primary

MeasureTime frame
Core phase: To assess rate of Multiple Sclerosis (MS) relapse over 2 years

Secondary

MeasureTime frame
Core and Extension Phase: proportion of the participants who have worsening or improving RRMS, Core and Extension Phase: occurrence of adverse events (type, severity and relationship to the study drug), Core and Extension Phase: early study discontinuation, Core and Extension Phase: measurements of the amount of ozanimod in a participant’s body

Countries

Italy, Poland, Portugal, Romania, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026