Pathophysiology of pain in Parkinson's disease: exploration of the serotonin system in positron emission tomography (PET [18F]-MPPF) - PD PAIN

Conditions

Parkinson's disease

Brief summary

The primary endpoint is the distribution volume ratio of [18F]-MPPF (DVR) using the cerebellum as the reference region, measured in both groups of painful and non-painful PD patients

Detailed description

assess the relationship between [18F]-MPPF uptake and :  central pain intensity, other central pain characteristics and pain-induced functional discomfort only in painful parkinsonian patients  pain perception thresholds in the 2 groups of patients, compare the functional networks related to pain on resting-state functional MRI between the 2 groups of patients;, evaluate, for the 2 groups of patients, the link between :  cerebral structural characteristics (cerebral macro/microstructural markers collected in MRI) and pain parameters (central pain intensity, and other pain characteristics, pain-induced functional discomfort and pain perception thresholds);  [18F]-MPPF uptake and pain-related functional networks in resting-state MRI

Related papers

No related papers found yet.

Interventions

DRUG18F-MPPF

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the distribution volume ratio of [18F]-MPPF (DVR) using the cerebellum as the reference region, measured in both groups of painful and non-painful PD patients	—

Secondary

Measure	Time frame
assess the relationship between [18F]-MPPF uptake and :  central pain intensity, other central pain characteristics and pain-induced functional discomfort only in painful parkinsonian patients  pain perception thresholds in the 2 groups of patients, compare the functional networks related to pain on resting-state functional MRI between the 2 groups of patients;, evaluate, for the 2 groups of patients, the link between :  cerebral structural characteristics (cerebral macro/microstructural markers collected in MRI) and pain parameters (central pain intensity, and other pain characteristics, pain-induced functional discomfort and pain perception thresholds);  [18F]-MPPF uptake and pain-related functional networks in resting-state MRI	—

Measure

Time frame

assess the relationship between [18F]-MPPF uptake and :  central pain intensity, other central pain characteristics and pain-induced functional discomfort only in painful parkinsonian patients  pain perception thresholds in the 2 groups of patients, compare the functional networks related to pain on resting-state functional MRI between the 2 groups of patients;, evaluate, for the 2 groups of patients, the link between :  cerebral structural characteristics (cerebral macro/microstructural markers collected in MRI) and pain parameters (central pain intensity, and other pain characteristics, pain-induced functional discomfort and pain perception thresholds);  [18F]-MPPF uptake and pain-related functional networks in resting-state MRI

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Countries

France

Outcome results

None listed