The influence of tramadol on opioid-induced bowel dysfunction

Conditions

Opioid induced bowel dysfunction

Brief summary

To evaluate total gastrointestinal transit time (MTS-2), To evaluate colorectal transit time

Detailed description

Subjective assessments of constipation (PAC-SYM, BSFS, GSRS, BFI), Diagnostic evaluation of opioid-induced constipation (Rome IV C6), Subjective assessment of opiate withdrawal (SOWS), Segmental transit time of the stomach, small intestine, and colonic segments (assessed with MTS-2), Detailed colonic motility (assessed with MTS-2), Colon volume (assessed with MRI), Water content in the colon (assessed with MRI), Gastric half emptying time (assessed with MRI), Gastric accommodation (assessed with MRI), Gastric motility (assessed with MRI), Small bowel motility (assessed with MRI), Small bowel water content (assessed with MRI)

Related papers

No related papers found yet.

Interventions

DRUGTRAMADOL

DRUGPlacebotablet 10mm

Eligibility

Sex/Gender

Male

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
To evaluate total gastrointestinal transit time (MTS-2), To evaluate colorectal transit time	—

Secondary

Measure	Time frame
Subjective assessments of constipation (PAC-SYM, BSFS, GSRS, BFI), Diagnostic evaluation of opioid-induced constipation (Rome IV C6), Subjective assessment of opiate withdrawal (SOWS), Segmental transit time of the stomach, small intestine, and colonic segments (assessed with MTS-2), Detailed colonic motility (assessed with MTS-2), Colon volume (assessed with MRI), Water content in the colon (assessed with MRI), Gastric half emptying time (assessed with MRI), Gastric accommodation (assessed with MRI), Gastric motility (assessed with MRI), Small bowel motility (assessed with MRI), Small bowel water content (assessed with MRI)	—

Measure

Time frame

Subjective assessments of constipation (PAC-SYM, BSFS, GSRS, BFI), Diagnostic evaluation of opioid-induced constipation (Rome IV C6), Subjective assessment of opiate withdrawal (SOWS), Segmental transit time of the stomach, small intestine, and colonic segments (assessed with MTS-2), Detailed colonic motility (assessed with MTS-2), Colon volume (assessed with MRI), Water content in the colon (assessed with MRI), Gastric half emptying time (assessed with MRI), Gastric accommodation (assessed with MRI), Gastric motility (assessed with MRI), Small bowel motility (assessed with MRI), Small bowel water content (assessed with MRI)

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Countries

Denmark

Outcome results

None listed