High-dosage fluoride toothpaste for root caries control (in situ): a randomized, controlled clinical trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2022-500059-22-01

Enrollment

Registered

2022-10-31

Start date

2023-03-24

Completion date

2024-04-22

Last updated

2024-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Phenomena and Processes (Fluoride in dental caries control)

Brief summary

Mineral loss / uptake in experimental bovine dental root slabs (in situ)

Detailed description

The fluoride concentration in saliva and biofilm (on the bovine dental root slabs)

Interventions

DRUGDuraphat

DRUGtandpasta

DRUGToothpaste (cosmetic product)

DRUGfluoride concentration: 1

DRUG450 ppm

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Mineral loss / uptake in experimental bovine dental root slabs (in situ)	—

Secondary

Measure	Time frame
The fluoride concentration in saliva and biofilm (on the bovine dental root slabs)	—

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026