VASODILATATION OR LOOP-DIURETICS FOR INITIAL TREATMENT OF PULMONARY CONGESTION DUE TO ACUTE HEART FAILURE – A RANDOMIZED PLACEBO-CONTROLLED TRIAL

Conditions

Acute heart failure with pulmonary congestion

Brief summary

Days alive and outside hospital until day 30

Detailed description

Intensification of therapy defineds as at least one of: mechanical ventilation, renal replacement therapy, vasopressors, inotropes, or mechanical heart failure treatment., Clinical benefit at 30 days, consisting of a composite of 1. All-cause death, 2. Intubation with mechanical ventilation, and 3. rehospitalization, , assessed using a ’win-ratio’ approach., NT-proBNP at day 1-3, Early Warning Score measured 6-24 hours after start of intervention, Adverse events, Patient-reported dyspnea assessment after 212--24 hours (7-point Likert scales in a standardized position: marked improvement from admission = 3, moderate improvement = 2, slight improvement = 1, no change = 0, slight worsening = -1, moderate worsening = -2, marked worsening = - 3

Related papers

No related papers found yet.

Interventions

DRUGIsoket

DRUGIsotonisk saltvand fremstillet af sygehusapoteket

DRUGFurosemide 10 mg/ml Solution for Injection or Infusion

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Days alive and outside hospital until day 30	—

Secondary

Measure	Time frame
Intensification of therapy defineds as at least one of: mechanical ventilation, renal replacement therapy, vasopressors, inotropes, or mechanical heart failure treatment., Clinical benefit at 30 days, consisting of a composite of 1. All-cause death, 2. Intubation with mechanical ventilation, and 3. rehospitalization, , assessed using a ’win-ratio’ approach., NT-proBNP at day 1-3, Early Warning Score measured 6-24 hours after start of intervention, Adverse events, Patient-reported dyspnea assessment after 212--24 hours (7-point Likert scales in a standardized position: marked improvement from admission = 3, moderate improvement = 2, slight improvement = 1, no change = 0, slight worsening = -1, moderate worsening = -2, marked worsening = - 3	—

Measure

Time frame

Intensification of therapy defineds as at least one of: mechanical ventilation, renal replacement therapy, vasopressors, inotropes, or mechanical heart failure treatment., Clinical benefit at 30 days, consisting of a composite of 1. All-cause death, 2. Intubation with mechanical ventilation, and 3. rehospitalization, , assessed using a ’win-ratio’ approach., NT-proBNP at day 1-3, Early Warning Score measured 6-24 hours after start of intervention, Adverse events, Patient-reported dyspnea assessment after 212--24 hours (7-point Likert scales in a standardized position: marked improvement from admission = 3, moderate improvement = 2, slight improvement = 1, no change = 0, slight worsening = -1, moderate worsening = -2, marked worsening = - 3

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Countries

Denmark

Outcome results

None listed