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Effect of Buffered Lidocaine on painless anesthesia in patients with painful teeth.

Effects of Buccal Infiltration of Buffered Lidocaine on the Success of Inferior Alveolar Nerve Block in Mandibular First Molars with Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626001014347
Enrollment
46
Registered
2026-08-18
Start date
2026-02-19
Completion date
Unknown
Last updated
2026-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study is being conducted to evaluate the effect of buffered lidocaine on anesthesia in mandibular molar teeth presenting with painful pulpitis. We hypothesize that buffering the lidocaine will make the anesthesia more effective ensuring a pain free root canal treatment for the patient.

Interventions

The procedure will be started by administering buccal infiltration with Sodium Bicarbonate mixed with 1% Lidocaine and Epinephrine in one group. Buffering of the local anesthetic will be performed with a hand mixing protocol. A 1ml sterile syringe will be used to withdraw 0.18 ml of local anesthetic solution from the 1.8 ml carpule followed by injection of 0.18 ml of sodium bicarbonate 8.4% solution into the carpule obtaining a ratio of 9:1 between the local anesthetic solution and the sodium bi

The procedure will be started by administering buccal infiltration with Sodium Bicarbonate mixed with 1% Lidocaine and Epinephrine in one group. Buffering of the local anesthetic will be performed with a hand mixing protocol. A 1ml sterile syringe will be used to withdraw 0.18 ml of local anesthetic solution from the 1.8 ml carpule followed by injection of 0.18 ml of sodium bicarbonate 8.4% solution into the carpule obtaining a ratio of 9:1 between the local anesthetic solution and the sodium bicarbonate. Every patient will be administered a buffered lidocaine carpule according to their wight. For every kg of weight, a 0.18ml buffered lidocaine solution will be used. After 15 minutes, lip numbness will be checked by asking the patient and if present, an inferior alveolar nerve block will be administered using 1% Lidocaine with 1:1000,000 Epinephrine. After another 15 minutes lip and tongue numbness will be confirmed again by asking the patient, and access cavity will be prepared. The treatment will be completed within 1 hour, and patient will be given a VAS to confirm their level of pain. VAS readings of 0 will be taken as ‘no pain’, 1-3 as ‘mild pain’, 4-7 as ‘moderate pain’ and 8-10 as ‘severe pain’. The total duration of the intervention will be 1 hour. The medical records will be reviewed to check if the patient follows regular appointments.

Sponsors

Dr. Fatima Ali - Watim Medical and Dental College
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

1. Patients aged 18–60 years. 2. Symptomatic irreversible pulpitis in mandibular 1st Molar teeth. 3. No periapical radiolucency on radiograph. 4. Vital pulp confirmed upon access. 5. No previously root canal treated tooth

Exclusion criteria

1. Allergies to any antibiotic used in the study. 2. Pregnant or lactating females. 3. Medically compromised patients. 4. Teeth with calcified canals or internal/external resorption. 5. Patients who used antibiotics or analgesics within the past 7 days.

Outcome results

None listed

Source: ANZCTR · Data processed: Aug 31, 2026