None listed
Conditions
Brief summary
This prospective single-centre randomized controlled trial investigates the effects of goal-directed haemodynamic therapy guided by FloTrac monitoring compared with conventional CVP/MAP-based management in adult patients undergoing kidney transplantation from brain-dead donors. Paired kidney recipients from the same donor are randomized 1:1 to intervention or control groups. The primary objective is to evaluate early graft function, particularly delayed graft function. Secondary outcomes include intraoperative haemodynamic parameters, fluid administration, vasopressor use, and early postoperative renal function. The study is conducted at Viet Duc University Hospital, Vietnam.
Interventions
Participants allocated to the intervention group will receive intraoperative goal-directed haemodynamic therapy guided by the FloTrac/Vigileo system via a radial arterial catheter.
The FloTrac/Vigileo system is applied immediately after induction of anaesthesia and maintained throughout the intraoperative period. Stroke volume index (SVI), cardiac index (CI), and stroke volume variation (SVV) are continuously monitored.
Fluid and vasoactive therapy are adjusted according to the haemodynamic pa
Participants allocated to the intervention group will receive intraoperative goal-directed haemodynamic therapy guided by the FloTrac/Vigileo system via a radial arterial catheter. The FloTrac/Vigileo system is applied immediately after induction of anaesthesia and maintained throughout the intraoperative period. Stroke volume index (SVI), cardiac index (CI), and stroke volume variation (SVV) are continuously monitored. Fluid and vasoactive therapy are adjusted according to the haemodynamic parameters obtained from the FloTrac/Vigileo system. The intervention is administered by anaesthesiologists experienced in haemodynamic monitoring. The intervention duration corresponds to the intraoperative period from induction of anaesthesia until completion of surgery.
Sponsors
Viet Duc University Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Adult patients aged 18–70 years with end-stage kidney disease undergoing deceased-donor kidney transplantation at Viet Duc University Hospital. Participants receiving a kidney from a brain-dead donor allocated through the paired-kidney randomisation process. Written informed consent provided.
Exclusion criteria
Severe cardiac arrhythmia or significant valvular heart disease. Left ventricular ejection fraction <40%. Intracardiac shunt or severe pulmonary hypertension. Combined organ transplantation. Inability to provide informed consent.
Outcome results
None listed