None listed
Conditions
Brief summary
Hearing loss in midlife is one of the biggest modifiable risk factors for a dementia diagnosis in later life. Sleep issues are also associated with both hearing loss and dementia but the link between hearing device use, cognitive decline and sleep is poorly understood. HAVENS will address this knowledge-gap in an Australian-first prospective study that uses a combination of innovative sensing techniques to assess cognition (electroencephalogram and functional near infrared spectroscopy sensing technologies), brain health (magnetic resonance imaging), sleep (domestic sleep sensing mattress), and physiological measures (wristband oximetry sensor for heartrate, breathing rate and oxygen saturation) in adults using hearing devices (103 hearing aid and 37 cochlear implant users). This project represents a paradigm shift as it will advance understanding of the impact of hearing interventions on human health.
Interventions
Brain magnetic resonance imaging (MRI) to study brain anatomy and function - this will take approximately 30 minutes; Brain neurovascular and electrophysiological function collected with functional near-infrared spectroscopy (fNIRS) - finger tapping test (12 minutes), stroop test (11 minutes), hearing test (15 minutes) and high-density electroencephalogram (EEG) sensing technologies - karolinska drowsiness test (10 minutes), biometric data collected by different sensors (including sleep measurem
Brain magnetic resonance imaging (MRI) to study brain anatomy and function - this will take approximately 30 minutes; Brain neurovascular and electrophysiological function collected with functional near-infrared spectroscopy (fNIRS) - finger tapping test (12 minutes), stroop test (11 minutes), hearing test (15 minutes) and high-density electroencephalogram (EEG) sensing technologies - karolinska drowsiness test (10 minutes), biometric data collected by different sensors (including sleep measurements, heartrate, breathing rate and oxygen saturation) - Withings undermattress every night for 3 years, Wristox for 3 nights, and blood extractions to detect blood markers for inflammation and dementia (10 minutes). Overall, followups will occur once a year during the 3 year period of the study.
Sponsors
Macquarie University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adults with hearing loss, specifically Hearing Aid users and/or Cochlear Implant recipients aged 40 years and older and residing at the Greater Sydney region.
Exclusion criteria
Participants will also be excluded for specific tests performed within this study if the criteria for those individual tests are not met. Specifically, if a participant has any cochlear implant that is not compatible with the MRI machine, or if they are/may be pregnant, they will be excluded from the MRI study.
Outcome results
None listed