Skip to content

He Aronga Hou: Reimagining Early Detection of Heart Risk for Maori Adults

Early Detection of Subclinical Cardiovascular Disease in Maori Adults Using Computed Tomography Coronary Angiography and N-Terminal Pro B-Type Natriuretic Peptide Testing: A Community-Led Feasibility Study

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000779370
Enrollment
100
Registered
2026-06-30
Start date
2026-07-20
Completion date
2027-07-31
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to investigate whether advanced heart screening can help identify early or previously undetected cardiovascular disease in Maori adults who are considered at intermediate risk of future heart disease. Participants will undergo heart imaging using computed tomography coronary angiography (CTCA), blood testing including N-terminal pro B-type natriuretic peptide (NT-proBNP), and cardiovascular risk assessment. The study will also evaluate whether this community-based, Maori health provider-led screening pathway is feasible, acceptable, and useful for improving early detection of heart disease in Maori communities. Researchers hypothesise that combining CTCA and blood biomarker testing will identify subclinical cardiovascular disease that may not be detected through standard cardiovascular risk assessment alone, allowing earlier intervention and management.

Interventions

What is the intervention The intervention is a community-based cardiovascular screening programme designed to support the early detection of subclinical cardiovascular disease in Maori adults at intermediate predicted cardiovascular risk. Participants undergo computed tomography coronary angiography (CTCA) with coronary artery calcium scoring and plaque assessment, blood biomarker testing including N-terminal pro B-type natriuretic peptide (NT-proBNP), and cardiovascular risk assessment. Partici

What is the intervention The intervention is a community-based cardiovascular screening programme designed to support the early detection of subclinical cardiovascular disease in Maori adults at intermediate predicted cardiovascular risk. Participants undergo computed tomography coronary angiography (CTCA) with coronary artery calcium scoring and plaque assessment, blood biomarker testing including N-terminal pro B-type natriuretic peptide (NT-proBNP), and cardiovascular risk assessment. Participants identified as higher risk are referred back to their primary care provider with cardiology-supported recommendations for further investigation and management. How participants will gain access to the intervention Participants will primarily be identified and referred through partnering Maori health providers and affiliated primary care/general practice services (e.g., Ngati Whatua Orakei, Ngati Porou Oranga, Turanga Health). Recruitment pathways may include: • Referral from primary healthcare providers or nurse-led clinics • Identification through existing cardiovascular risk assessment programmes • Community outreach and provider-led engagement • Self-expression of interest following community promotion approved by partner organisations Once referred, participants will be contacted by the research/provider team to confirm eligibility and arrange screening appointments. Who delivers it and their relevant expertise The study is delivered collaboratively by Maori health providers, the research team, radiology services, and cardiology specialists. Maori health provider research staff and coordinators support recruitment, consent, participant engagement, and study logistics within their communities. CTCA imaging is performed by trained radiographers and overseen by radiologists and cardiologists experienced in cardiovascular imaging. The study team includes researchers and clinicians with expertise in cardiovascular medicine, Maori health, and community-based health research. Training and support for radiographers and clinical staff Radiographers and relevant clinical staff involved in CTCA and echocardiography procedures are already appropriately qualified and experienced in delivering these clinical assessments as part of standard practice. Prior to commencement of participant enrolment, the study team will provide: • Study-specific orientation regarding referral pathways, participant flow, and research processes • Guidance on study documentation and communication procedures • Clarification of escalation pathways for incidental or clinically significant findings • Cultural safety expectations and kaupapa Maori principles underpinning the project This orientation/training will occur prior to the first participant enrolment and will include 1-2 online briefings Timing of training relative to assessment period All study orientation and relevant staff training will occur before participant recruitment and commencement of assessments. Ongoing communication and support will be available throughout the study period as needed. How it is delivered The study is delivered primarily through face-to-face interactions within Maori health provider settings and clinical imaging services. Participant recruitment and consent occur kanohi ki te kanohi (face-to-face) with support from Maori health provider staff and research personnel. Screening procedures are delivered individually. Follow-up communication may occur by phone or email where appropriate. How often and for how long Participants complete a single screening pathway over approximately 1–3 months, depending on scheduling and follow-up requirements. This includes one baseline assessment and blood test appointment, one CTCA imaging appointment, and additional follow-up investigations (e.g., echocardiography) if clinically indicated based on screening findings. Approximate duration of appointments and follow-up visits Estimated participant time commitments are: Initial screening/consent visit: 30–60 minutes Blood test appointment: 15–20 minutes CT Coronary Angiography (CTCA): 45–90 minutes Echocardiography (if indicated): 30–60 minutes Follow-up discussion/results review: 20–40 minutes Some participants may require additional clinical follow-up depending on screening findings and referral Where it is delivered The intervention is delivered through Maori health provider clinics and associated clinical services in Auckland and Tairawhiti/Gisborne. CTCA scans are undertaken at participating radiology services, including The Heart Group in Auckland and Gisborne Hospital. Adherence Participant engagement and adherence are supported through ongoing communication from Maori health provider coordinators and research staff. Appointment scheduling assistance, reminder phone calls, text messages, and follow-up contact are used to support attendance and completion of study procedures. The community-led nature of the project and involvement of trusted local providers are intended to support participant retention and engagement throughout the screening pathway.

Sponsors

Manawaora Integrated Health and Research
Lead SponsorOther

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
30 Years to 59 Years
Healthy volunteers
No

Inclusion criteria

Inclusion Criteria: • Maori men aged 30–59 years • Maori women aged 40–59 years • Classified as intermediate risk (5–14% five-year CVD risk) using the PREDICT tool • Able to provide informed consent

Exclusion criteria

Exclusion Criteria: • Previous diagnosis of ischaemic heart disease or heart failure • Contraindications to CTCA (e.g., contrast allergy, renal impairment [defined as eGFR 300ms) • Pregnancy

Outcome results

None listed

Source: ANZCTR · Data processed: Jul 23, 2026