Positive framing on perceptions of biologic treatment for inflammatory bowel disease: An intervention study

The intervention is based on that developed by Yielder et al. (2025), which was validated in a sample of Rheumatoid Arthritis patients prescribed methotrexate. The intervention has been adapted for Inflammatory Bowel Disease (IBD) patients prescribed any of the funded biologics. The intervention consists of a 5-minute video comprised of 'talking heads', voiceover and information text on screen. The video starts by providing standard information about biologic treatment. The video then explains the potential symptoms and experiences that may occur as result of taking biologic treatments and patient mindsets towards the medication are addressed by framing potential symptoms as positive signals that the treatment is working inside the body. The video informs patients of the importance of ongoing monitoring of health while taking their treatment and will distinguish between non-severe symptoms that may cause discomfort but are medically safe, and severe side effects that are picked up and monitored through regular blood tests. The intervention has been reviewed for medical accuracy by an IBD Nurse Practitioner at Middlemore Hospital. The intervention will be delivered by tablet by a student researcher at the patient's routine biologic education clinic appointment or at their infusion appointment. Patients will also receive a pamphlet explaining the key points of the video. They will also receive a booster phone call from the student researcher two weeks later to remind them of the topics covered in the video. The video and pamphlet were designed specifically for this study.