None listed
Conditions
Brief summary
The aim of the study is to determine whether the structure of kiwifruit affects the bioavailability of folate, vitamin C, and potassium, and whether this differs between varieties. The study will be a randomised, crossover, clinical intervention study. There will be 5 interventions (arms) and they will be 4 different kiwifruit varieties and a comparator supplement in the form of a capsule. Each arm will take 24 hours to complete. Samples will be taken at designated timepoints to measure the concentration of folate, vitamin C and potassium in blood and urine.
Interventions
This is a 5 arm, randomised, crossover study which includes 5 study days separated by a washout period of at least 5 days. At each visit, participants will consume one of the following:
Arm 2: 200 g Zespri Green Hayward (intervention)
Arm 3: 200 g Zespri SunGold Gold3 (intervention)
Arm 4: 200 g Zespri RubyRed Red19 (intervention)
Arm 5: 200 g Zespri Red80 (intervention).
By the end of the study, participants would have received all 5 study interventions. Each arm spans 24 hours. Participant
This is a 5 arm, randomised, crossover study which includes 5 study days separated by a washout period of at least 5 days. At each visit, participants will consume one of the following: Arm 2: 200 g Zespri Green Hayward (intervention) Arm 3: 200 g Zespri SunGold Gold3 (intervention) Arm 4: 200 g Zespri RubyRed Red19 (intervention) Arm 5: 200 g Zespri Red80 (intervention). By the end of the study, participants would have received all 5 study interventions. Each arm spans 24 hours. Participants must consume their intervention within 5 minutes from the first bite. Interventions will be delivered face to face by a Research Associate who has many years experience in participant management during clinical studies. Participants will be supervised by a member of the research team to monitor adherence. Participants will remain on site for the initial 4 hours of the study arm. There are additional timepoints at 8, 12 and 24 hours. Participants may leave the facility after the 4 hour timepoint but must ensure that they return well before the next sampling time. All visits will take place at the Bioeconomy Science Institute (BSI) Human Clinical Research Facility.
Sponsors
Bioeconomy Science Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
An individual of any sex, aged 18 to 50 years
Exclusion criteria
Participants will be excluded if they are allergic to, or intolerant of, kiwifruit or constituents of the comparator supplement. In addition, volunteers will be excluded if they are pregnant, planning to get pregnant in the near future or are breast feeding. They must not have any of the following: blood-borne diseases (e.g. hepatitis) taking medication that affects the properties of blood (e.g. blood clotting) have a chronic illness (e.g. cancer) taking medication for weight loss (e.g. Wegovy, Ozempic, Saxenda) taking medication for mood disorders. Volunteers who smoke or vape are also ineligible to take part.
Outcome results
None listed