None listed
Conditions
Brief summary
To characterise current ventilatory practices and adherence to low tidal volume ventilation (LTVV) in the management of patients with acute hypoxaemic respiratory failure (AHRF) receiving invasive ventilation in intensive care units in Australia and New Zealand.
Interventions
Spontaneous breathing is defined as a total respiratory rate above the set respiratory rate during invasive ventilation. Details from routinely collected data will be recorded for the purposes of the study retrospectively. These include ventilatory variables observed (Set and total respiratory rate, set and measured tidal volume, peak inspiratory pressures, positive end expiratory pressure (PEEP), and fraction of inspired oxygen (FiO2)), vital signs observed and recorded on the ICU medical recor
Spontaneous breathing is defined as a total respiratory rate above the set respiratory rate during invasive ventilation. Details from routinely collected data will be recorded for the purposes of the study retrospectively. These include ventilatory variables observed (Set and total respiratory rate, set and measured tidal volume, peak inspiratory pressures, positive end expiratory pressure (PEEP), and fraction of inspired oxygen (FiO2)), vital signs observed and recorded on the ICU medical record, specific treatments prescribed (Sedation, analgesia, vasoactive medications, neuromuscular blockade), and adjunctive treatments prescribed or used (Prone positioing, renal replacement therapy, extracorporeal membrane oxygenation, tracheostomy, extubation, and reintubation) for the first five days from enrolment, Outcome data will be collected at day 28 including duration of invasive ventilation, and mortality, Patients will not be participating in questionnaires.
Sponsors
Medical Research Institute of New Zealand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Eligible participants are patients that meet all the inclusion criteria below: 1) aged 18 or older 2) Receiving invasive ventilation and expected to remain invasively ventilated for at least 24 hours. 3) acute hypoxaemic respiratory failure, defined as one of the following criteria: a) arterial partial pressure of oxygen measured on an arterial blood gas : Fraction of inspired oxygen < 300 mmHg b) Peripheral pulse oxymeter saturations: Fraction of inspired oxygen < 315 mmHg (if peripheral oxygen saturations < 97%) 4) acute hypoxaemic respiratory failure onset on invasive ventilation in ICU within the last 24 hours
Exclusion criteria
1) Patient received invasive ventilation for > 72 hours at time of eligibility. 2) Patients admitted with a traumatic brain injury 3) Admission with severe life-threatening asthma 4) Previous medical history of severe chronic obstructive pulmonary disease (COPD) 5) Chronic or acute neuromuscular disease 6) Patients on extracorporeal membrane oxygenation (ECMO) 7) Patients admitted with an unsurvivable illness or potential organ donation.
Outcome results
None listed