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Screening for primary aldosteronism in postpartum women who have chronic hypertension

Screening for primary aldosteronism (PA) after hypertensive pregnancy: determining prevalence of PA in women who have pre-existing or new chronic hypertension after a hypertensive pregnancy

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12626000619347
Enrollment
600
Registered
2026-05-20
Start date
2026-06-15
Completion date
2027-06-15
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

International guidelines now recommend screening for primary aldosteronism (PA) in people with chronic hypertension, however this is often not done. Unlike essential hypertension, PA has specific treatments, some of which can even provide a cure. Pregnancy and the postpartum provides a window of opportunity to screen women and improve their longterm health outcomes. However we don't know the prevalence of PA in this population. We aim to determine the prevalence of PA in women who have chronic hypertension after pregnancy. With a pragmatic design, we also aim to provide both quantitative and qualitative data on performing initial screening on medications commonly used in the postpartum period.

Interventions

Women who had hypertension will be followed up postpartum. PA screening is now recommended for all adults with hypertension. For those with pre-existing chronic hypertension, screening for PA will be performed at 6 weeks postpartum. For those with de novo hypertension, an assessment will be completed at 3 months postpartum to assess whether hypertension has resolved or continued (now meeting criteria for chronic hypertension). If new chronic hypertension is diagnosed then PA screening will be pe

Women who had hypertension will be followed up postpartum. PA screening is now recommended for all adults with hypertension. For those with pre-existing chronic hypertension, screening for PA will be performed at 6 weeks postpartum. For those with de novo hypertension, an assessment will be completed at 3 months postpartum to assess whether hypertension has resolved or continued (now meeting criteria for chronic hypertension). If new chronic hypertension is diagnosed then PA screening will be performed. If screening tests are positive, participants will proceed to confirmatory testing with their local endocrine department.

Sponsors

Eastern Health Clinical School
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Diagnosis of chronic hypertension, gestational hypertension, postpartum hypertension or preeclampsia

Exclusion criteria

Known diagnosis of primary aldosteronism

Outcome results

None listed

Source: ANZCTR · Data processed: May 30, 2026