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A memory-based digital intervention (MemFlex) for young people struggling with low mood

A randomised control trial of the effect of digital memory flexibility training (MemFlex) on depressive symptoms in young people

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000592347
Enrollment
60
Registered
2026-05-12
Start date
2026-05-18
Completion date
2027-12-01
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Here, we aim to evaluate the app-version of a simple, memory-based program MemFlex. A paper version of the program has been previously evaluated in young people and was demonstrated to improve symptoms of depression and ameliorate cognitive difficulties that predict prognosis and impede the efficacy of psychological therapy (Mirabolfathi et al., 2024). Our key aim is to determine the acceptability of the app-based delivery of MemFlex to young people, as well as assess whether the program may improve symptoms of depression and autobiographical memory bias, known to be a cognitive predictor of mental ill-health.

Interventions

MemFlex; The MemFlex intervention aims to improve the ability to retrieve any autobiographical memory type on demand, using cued recall exercises. Participants are never asked to retrieve negative memories or trauma memories. In particular, the intervention trains three core skills: balancing, elaboration, and flexibility. Balancing aims to improve access to personally relevant memories that are emotionally positive. Improving ease of access to positive autobiographical information aims to balan

MemFlex; The MemFlex intervention aims to improve the ability to retrieve any autobiographical memory type on demand, using cued recall exercises. Participants are never asked to retrieve negative memories or trauma memories. In particular, the intervention trains three core skills: balancing, elaboration, and flexibility. Balancing aims to improve access to personally relevant memories that are emotionally positive. Improving ease of access to positive autobiographical information aims to balance against the negative self-appraisals that drive depression. Elaboration aims to increase the detail and vividness of these positive memories. Flexibility explicitly trains the ability to move between specific and general levels of memory representation. These skills are gradually introduced and built upon via ten online self-guided sessions. A 45 minute orientation Zoom call with a support worker introduces the intervention. Participants are emailed a link to access the online sessions, which involve an initial psychoeducation component, and memory recall exercises using memory cues. In the sessions, participants are trained to recall event memories and general memories, to elaborate memories with contextual, emotional and somatic details, and to flexibly move between memory types. Participants are encouraged to complete 2-3 online, self-guided sessions (~15 mins) per week for 4 weeks, and can contact their support worker via email or phone number with any questions. Treatment adherence is monitored by the support worker through website analytics. The support worker will check in with participants after 2 weeks, then after 4 weeks following orientation, by either email, text message, or phone call depending on participant preference. MemFlex participants will be able to continue any other offered activities (e.g., medication, psychological therapy). We will record access to services for each participant. That is, a MemFlex plus treatment as usual design will be used. As the intervention is entirely online, including contact with the support worker, participants can access the program when and where they feel comfortable to do so. After completing the final survey, participants will be offered access to the BrightMind program.

Sponsors

The University of Melbourne
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator)

Eligibility

Sex/Gender
All
Age
12 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

Score of 10 or above on the Patient Health Questionnaire (PHQ-9; Kroenke et al., 2003), proficiency in reading and writing English, and have access to a computer.

Exclusion criteria

Have a medically confirmed diagnosis of cognitive impairment.

Outcome results

None listed

Source: ANZCTR · Data processed: May 22, 2026