None listed
Conditions
Brief summary
Children aged 8–12 years will undergo standardized local warming of the antecubital region of one arm, previously administered a topical numbing cream. Ultrasound will be used to assess changes in venous diameter over a 30-minute warming period, and venous compressibility will be measured before and after warming, with and without tourniquet pressure. We hypothesize that warming increases vein size in children, but that topical numbing cream may delay the vasodilatory response, requiring longer warming durations than those typically used in clinical practice.
Interventions
Participants undergo controlled local warming of the antecubital fossae using a infrared LED (IR-LED) heating unit. Skin temperature is continuously monitored and the temperature is regulated to remain a skin temperature within 38–42 °C. Local warming is applied for 30 minutes.
Ultrasound is used to assess venous diameter repeatedly during warming and to assess venous compressibility/compliance before and after warming, both without venous occlusion and during venous occlusion at 40 mmHg using a
Participants undergo controlled local warming of the antecubital fossae using a infrared LED (IR-LED) heating unit. Skin temperature is continuously monitored and the temperature is regulated to remain a skin temperature within 38–42 °C. Local warming is applied for 30 minutes. Ultrasound is used to assess venous diameter repeatedly during warming and to assess venous compressibility/compliance before and after warming, both without venous occlusion and during venous occlusion at 40 mmHg using a pneumatic pressure cuff. Topical anesthetic cream containing lidocaine and prilocaine is applied to the skin prior to warming. The cream is removed 60–90 minutes after application and within 15 minutes prior to warming. The anesthetic is not evaluated as a treatment but constitutes a background condition under which physiological venous responses are studied. All procedures are performed by trained research staff in a controlled clinical environment.
Sponsors
Karolinska University Hospital, Department of Research & Development
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
8 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy children aged 8–12 years
Exclusion criteria
Any medical history or current condition that may influence vascular function or otherwise affect study outcomes Presence of damaged, irritated, inflamed, or otherwise compromised skin in the antecubital region Known allergy or hypersensitivity to topical anaesthetic creams containing lidocaine and prilocaine
Outcome results
None listed