None listed
Conditions
Brief summary
A comparative study of 80% TCA with cryotherapy versus cryotherapy alone in plantar warts will be conducted at Dermatology out-patient department , PNS Shifa hospital Karachi after fullfilling the inclusion and exclusion criteria. After the informed written consent and permission from hospital's ethics review committee ,50 patients will be divided in Group A and Group B. Patients in both group will receive treatment till clearance of the plantar warts and data from patient will be collected through a porforma on first visit and follow-ups. We hypothesize that combination therapy using trichloroacetic acid (TCA) with cryotherapy is more effective than cryotherapy alone in the treatment and removal of warts.
Interventions
Patients will be divided in two groups.
In Group A, cryotherapy will be performed by the investigator using liquid nitrogen applied via spray or cotton-tipped applicator for 10–15 seconds in two freeze–thaw cycles at 2-week intervals for up to six sessions or until clearance.
Sponsors
Pakistan Naval Ship Shifa Hospital Karachi
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
12 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1)Age 12 years and above , both genders. 2)Clinically diagnosed plantar warts confirmed by paring to demonstrate thrombosed capillaries. 3)Lesions 5 or more in number or mosaic plaques less than or equal to 4 cm in diameter. 4)Willingness to provide informed consent and adhere to follow-up.
Exclusion criteria
1)Immunocompromised patients (HIV, systemic steroid or chemotherapy use). 2)Peripheral vascular disease, diabetic foot, or neuropathy. 3)Pregnancy or lactation. 4)Local infection, ulceration, or recent treatment with TCA/cryotherapy (within 4 weeks). 5)Allergy to TCA or inability to tolerate cryotherapy.
Outcome results
None listed