None listed
Conditions
Brief summary
HYPOTHESIS: There is a difference in mean inter-appointment pain using Triple Antibiotic Paste and Chlorhexidine, in teeth with Symptomatic Apical Periodontitis. The aim of this study is to compare the mean difference in inter-appointment pain in patients with Symptomatic Apical Periodontitis to determine whether a combination of antibiotics such as TAP or simple Chlorhexidine gel is more effective for pain relief at 48 hours after canal preparation in multiple-visit routine Root canal treatment. Therefore, this will help in recommending the most appropriate intracanal medicament to be used in between appointments for effective pain relief.
Interventions
Patients will be divided into two equal groups
Group 2 will receive Triple Antibiotic Paste (TAP) as intracanal medicament.
TAP contains Ciprofloxacin 500mg, Metronidazole 400mg and Minocycline 100mg in 1:1:1. A powder is made and then mixed with Normal saline to form a paste.
Amount administered is approximately 0.5 to 1ml (root canal is filled from root apex till canal orifice)
Medicaments are placed inside the Root canal system for at least 1 week between the 1st and 2nd appointment i.e. af
Patients will be divided into two equal groups Group 2 will receive Triple Antibiotic Paste (TAP) as intracanal medicament. TAP contains Ciprofloxacin 500mg, Metronidazole 400mg and Minocycline 100mg in 1:1:1. A powder is made and then mixed with Normal saline to form a paste. Amount administered is approximately 0.5 to 1ml (root canal is filled from root apex till canal orifice) Medicaments are placed inside the Root canal system for at least 1 week between the 1st and 2nd appointment i.e. after pulpectomy and initial Cleaning and shaping in 1st visit of Root Canal Treatment. It is removed in the 2nd visit. Medicament is placed by the treating dentist (postgraduate resident in Operative Dentistry and Endodontics) Number of appointments (2 to 3 appointments approximately 1 week apart) Mean pain score at 48 hours after placement of medicament will be recorded.
Sponsors
Dr. Mashaal Nadeem - Watim Medical and Dental College
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Patients presenting with the following will be included: 1. Anterior/ posterior teeth with a single - canal; 2. Symptomatic teeth with Apical Periodontitis; and 3. Necrotic teeth with negative response to vitality testing.
Exclusion criteria
Patients presenting with the following will be excluded: 1. Presence of endo-perio lesions; 2. Teeth that have an acute or chronic apical abscess; 3. Teeth associated with chronic periodontitis; 4. Teeth having open apices, calcified canals, or severe dilacerations; 5. Patients taking medication that could influence pain perception; and 6. Medically compromised patients with systemic or immunocompromised diseases (AIDS, HBV etc.)
Outcome results
None listed