None listed
Conditions
Brief summary
This trial aims to determine changes in the control of breathing in the supine posture (lying flat on your back), before and after bronchodilator therapy and the link with breathing discomfort and sleep in people with chronic obstructive pulmonary disease. Non-invasive recordings of brain activity, termed electroencephalography, will be used to determine changes in the control of breathing that occur with change from seated to supine posture, and after bronchodilator therapy. The link between changes in the control of breathing with breathing discomfort during these conditions (assessed by questionnaire) and sleep quality (assessed by an under-mattress sensor and sleep diaries). Baseline lung function and questionnaire responses will be collected.
Interventions
Participants will be under go 3 consecutive interventions of 15 minutes each in duration:
1. A change in posture from the seated to the supine posture. Direct observation will be used to assess adherence.
2. Participants will receive 400ug of Salbutamol (i.e. 4 metered doses), once off in the laboratory. Participants will self-administer the salbutamol, inhaled via an actuator and spacer, under supervision in the supine posture. Direct observation will be used to assess adherence. All particip
Participants will be under go 3 consecutive interventions of 15 minutes each in duration: 1. A change in posture from the seated to the supine posture. Direct observation will be used to assess adherence. 2. Participants will receive 400ug of Salbutamol (i.e. 4 metered doses), once off in the laboratory. Participants will self-administer the salbutamol, inhaled via an actuator and spacer, under supervision in the supine posture. Direct observation will be used to assess adherence. All participants will receive the medication and comparisons will be made before and after the medication. 3. Participants will receive ventilatory support in the supine posture, e.g. pressure support delivered via a face mask, up to 10cmH2O. This will occur for 15 minutes. Direct observation will be used to assess adherence.
Participants will be under go 2 consecutive interventions of 15 minutes each in duration:
1. A change in posture from the seated to the supine posture. Direct observation will be used to assess adherence.
2. Participants will receive 400ug of Salbutamol (i.e. 4 metered doses), once off in the laboratory. Participants will self-administer the salbutamol, inhaled via an actuator and spacer, under supervision in the supine posture. Direct observation will be used to assess adherence. All particip
Participants will be under go 2 consecutive interventions of 15 minutes each in duration: 1. A change in posture from the seated to the supine posture. Direct observation will be used to assess adherence. 2. Participants will receive 400ug of Salbutamol (i.e. 4 metered doses), once off in the laboratory. Participants will self-administer the salbutamol, inhaled via an actuator and spacer, under supervision in the supine posture. Direct observation will be used to assess adherence. All participants will receive the medication and comparisons will be made before and after the medication.
Sponsors
Flinders University
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Doctor-diagnosis of chronic obstructive pulmonary disease Score of 2 or more on the modified Medical Research Council scale for exertional dyspnoea
Exclusion criteria
Recent chronic obstructive pulmonary disease exacerbation (< 6 weeks). Low English proficiency (i.e. inability to give informed consent). Any relevant malignancy, significant cardiorespiratory disease, coexisting neurological disorder, use of oxygen or high-flow therapy. Inability or unwillingness to use consumer technology, i.e. no smartphone or wifi at home.
Outcome results
None listed