Skip to content

CLinician-perfOrmed bedside ulTrasound for Screening for Proximal deep venOus Thrombosis in Intensive Care Unit (the CLOT-SPOT study)

CLinician-perfOrmed bedside ulTrasound for Screening for Proximal deep venOus Thrombosis in the ICU (CLOT-SPOT): A prospective observational diagnostic accuracy study

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000315314
Enrollment
100
Registered
2026-03-12
Start date
2026-04-01
Completion date
2027-03-31
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This prospective observational study aims to evaluate bedside two-zone lower limb compression point-of-care ultrasound (POCUS) for the detection of deep vein thrombosis (DVT) in critically ill adults.

Interventions

Description of the intervention The intervention involves a bedside two-zone lower limb compression point-of-care ultrasound (POCUS) to screen for proximal deep vein thrombosis. Using a high-frequency linear probe, compression is applied at two standard zones: the common and superficial femoral vein and the popliteal vein. The participant is positioned supine with appropriate limb positioning. Vein compressibility is assessed in real time. The procedure is non-invasive and performed at the bedsi

Description of the intervention The intervention involves a bedside two-zone lower limb compression point-of-care ultrasound (POCUS) to screen for proximal deep vein thrombosis. Using a high-frequency linear probe, compression is applied at two standard zones: the common and superficial femoral vein and the popliteal vein. The participant is positioned supine with appropriate limb positioning. Vein compressibility is assessed in real time. The procedure is non-invasive and performed at the bedside. Frequency and duration Each scan will take approximately 5–10 minutes and will not exceed 15 minutes per episode. Scans will be performed at predefined time points according to the study protocol. Training of junior ICU medical staff Prior to study commencement, junior staff will receive a brief face-to-face orientation (approximately 1 hours) delivered by an experienced operator in POCUS, covering study procedures and how to assist during scanning. Location and setting All ultrasounds will be performed at the participant’s bedside in the intensive care unit. No patient transfer is required. Monitoring adherence and fidelity A standardized scanning protocol and data collection form will be used. Scan timing, anatomical sites assessed, and image adequacy will be documented.

Sponsors

Austin Health
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Primary purpose
Diagnosis

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

• Any ICU patients • Treating team has requested a formal lower limb venous duplex ultrasound for suspected DVT (any indication, unilateral or bilateral). • Feasible to perform bedside POCUS within a defined time window (e.g., before the formal scan takes place). For ICU staff: - Any ICU registrar working at Austin health within the study period

Exclusion criteria

• Formal radiology-duplex ultrasound scan performed before bedside DVT POCUS • Formal scan performed >48h after POCUS • Known previously documented proximal DVT in the same limb within the current admission (confounder variable) • Extensive lower limb wounds or devices precluding adequate probe access • Clinical instability where POCUS is deemed unsafe.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 20, 2026