None listed
Conditions
Brief summary
The CAMAS study is a prospective, longitudinal observational cohort study examining the effects of long-term anaerobic exercise on myocardial structure and function. Adults with predominantly anaerobic gym training are compared with individuals undertaking predominantly aerobic exercise using cardiac magnetic resonance imaging (CMR) and electrocardiography. Blood samples are collected for exploratory molecular analyses where funding permits. Participants are followed annually for up to ten years to document cardiac diagnoses and cardiovascular events. The study aims to identify imaging-based phenotypes associated with anaerobic exercise and potential cardiovascular risk.
Interventions
The CAMAS study is a prospective, longitudinal observational exposure study (no intervention). Participants are enrolled based on exercise exposure:
a) Exposure group (anaerobic): adults (at least 18 years) with approximately 5 years of predominantly anaerobic gym training (at least 3 days/week, at least 120 min/week, including at least 1 lower body session/week); anaerobic group additionally requires ability to bench press and squat at least their body weight (kg).
All enrolled participants u
The CAMAS study is a prospective, longitudinal observational exposure study (no intervention). Participants are enrolled based on exercise exposure: a) Exposure group (anaerobic): adults (at least 18 years) with approximately 5 years of predominantly anaerobic gym training (at least 3 days/week, at least 120 min/week, including at least 1 lower body session/week); anaerobic group additionally requires ability to bench press and squat at least their body weight (kg). All enrolled participants undergo a baseline research assessment comprising a questionnaire (anticipated to take approximately 10-15 minutes); 12-lead digital ECG, venous blood sampling, and cardiac MRI (CMR) (approximately 1 hour). Participants are followed annually for up to 10 years to capture interim cardiac diagnoses and cardiovascular events.
Sponsors
The University of Sydney
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1) Adults aged at least 18 years 2) Male or female 3) Regular exercise training for at least 5 years (at least 3 gym sessions/week, at least 120 minutes/week, including at least 1 lower body session/week) 4) Predominantly anaerobic or predominantly aerobic exercise history (per study group definitions) 5) Ability to comply with study procedures 6) Able to provide written informed consent
Exclusion criteria
A) Contraindication to cardiac MRI (e.g. pacemaker or other ferromagnetic implants, severe claustrophobia, inability to fit in scanner) B) Known cardiovascular disease or inflammatory cardiac conditions (ischaemic heart disease, cardiomyopathy, myocarditis, or pericarditis) C) Recent or significant COVID-19 infection (within 6 months, or requiring antiviral therapy or hospitalisation) D) Family history of cardiomyopathy or inherited arrhythmogenic cardiomyopathy E) Current or recent substance exposures likely to confound outcomes (illicit recreational drug use, alcohol abuse, tobacco smoking within 10 years) F) Use of medications that may confound cardiac structure or function (anti-obesity drugs, regular anti-inflammatory drug use)
Outcome results
None listed