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Critical ingredients of multilevel aphasia interventions for people with post-stroke aphasia

Identifying the critical ingredients of multilevel aphasia interventions for people with post-stroke aphasia

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000262303
Enrollment
20
Registered
2026-03-03
Start date
2026-03-09
Completion date
2027-04-01
Last updated
2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study aims to extend understanding and use of multilevel interventions in managing aphasia, focusing on identifying the critical ingredients of multilevel aphasia interventions and the role of discourse (connected speech) in bringing about change. Through comparison between Verb Network Strengthening Treatment (VNeST) which targets improved word finding and sentence production by emphasising verbs and the roles of other words in a sentence, and Narrative and Discourse Intervention in Aphasia (NADIIA) which also targets words and sentences through work on verbs and their roles, but embeds practice within connected speech and introduces discourse frameworks that organise ideas in daily, functional speaking contexts. Twenty adults with aphasia will participate, with 10 in each therapy group. Language improvements and their impact on daily communication will be measured. It is predicted that both interventions will improve word retrieval and sentence structure, but NADIIA will lead to greater gains in connected speech and discourse structure than VNeST.

Interventions

Verb Network Strengthening Treatment (VNeST), is an intervention targeting word and sentence levels. VNEST aims to improve word finding and sentence production by focusing on verbs and the roles of other words in a sentence. Materials Required for VNeST (Intervention) VNeST is designed to require minimal materials. For each session, the following items will be used: 1. Pen and paper, or a small tabletop whiteboard with dry erase markers 2. Pre prepared simple sentences for Step 4 (sentences ma

Verb Network Strengthening Treatment (VNeST), is an intervention targeting word and sentence levels. VNEST aims to improve word finding and sentence production by focusing on verbs and the roles of other words in a sentence. Materials Required for VNeST (Intervention) VNeST is designed to require minimal materials. For each session, the following items will be used: 1. Pen and paper, or a small tabletop whiteboard with dry erase markers 2. Pre prepared simple sentences for Step 4 (sentences may also be created during the session if required) 3. For the optional Step 5 activity, one picture per target verb per week Intervention Procedures Step 1: The participant generates several scenarios (typically three) incorporating the target verb. This activity is intended to activate and strengthen the participant’s verb network by eliciting a range of possible agents and objects related to the verb. Step 2: The participant reads each scenario aloud three times. This promotes repeated production and consolidation of complete sentences and reinforces basic subject–verb–object sentence structure. Step 3: The participant selects one scenario from Step 1 and answers three WH questions (where, when, why). This step encourages production of more detailed and complex sentences and supports engagement with semantic, world, and autobiographical knowledge relevant to the event. Step 4: The clinician reads simple active sentences containing the target verb, and the participant determines whether each sentence is semantically accurate. This activity supports sentence level comprehension and the ability to distinguish and relate individual word meanings. Step 5: The participant is asked to name the target verb they have been working on. This step assesses independent retrieval of the verb. Step 6: The participant repeats Step 1 without cues, providing an opportunity for independent production of scenarios following completion of the earlier intervention activities. Intervention Provider The intervention will be delivered by a student researcher, a qualified speech pathologist with training in aphasia therapy delivery. All intervention activities will occur under the supervision of the principal investigator. Intervention Frequency and Duration • Weeks 1–2: Baseline assessments • Weeks 3–12: Intervention phase (two one hour sessions per week for 10 weeks) • Weeks 13–14: Post intervention assessments • Week 18: Follow up assessment Total participation duration will be approximately 18 weeks. Mode of Delivery Therapy will be provided either in person or via a secure telepractice platform (COVIU). The mode of delivery will be determined by participant preference and geographic location. Adherence and Fidelity Monitoring To ensure fidelity to the intervention protocol: • One therapy session per participant per week will be video recorded and reviewed against the protocol’s essential elements. • Any deviations from the protocol will be reviewed with the Supervisory Team and documented for inclusion in analyses. • The student researcher will complete standardised data collection forms, maintain a fidelity log, and record detailed therapy information for each participant, including treatment dosage and intensity (session number, timing, and duration).

Sponsors

University of Tasmania
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

A person who meets the following criteria will be invited to take part in the study: 1. Has experienced a stroke of any type (stroke defined by ICD-10 codes 161-164), as confirmed by medical records. 2. Is medically stable at the time of recruitment and suitable for rehabilitation. 3. Is at least 6 weeks post-stroke (there is no upper time limit). 4. Has mild to severe aphasia of any type, as determined by the Western Aphasia Battery–Revised AQ (WAB-R, Kertesz, 2007) (Severe: 26-50, Moderate: 51-75, Mild: 76-93.8). 5. Has normal or corrected hearing and vision. 6. Was proficient in English before the stroke, and used English in daily communication (no interpreter required for therapy). 7. May have mild speech difficulties, such as dysarthria or apraxia of speech, provided these are not the main cause of communication difficulty.

Exclusion criteria

People will not be eligible to participate if they: 1. Have a primary speech impairment such as apraxia of speech or dysarthria that is moderate to severe. 2. Have been diagnosed with dementia. 3. Have a history of significant head injury or neurosurgery. 4. Have another progressive neurological condition (for example, Parkinson’s disease). 5. Have a clinically diagnosed major depression that may affect participation. 6. Are currently taking part in another aphasia-related research trial.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 14, 2026