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Longitudinal monitoring of anterior cruciate ligament integrity in youth female rugby league athletes

Longitudinal monitoring of anterior cruciate ligament integrity in youth female rugby league athletes: protocol for a randomised, parallel-group study integrating quantitative MRI, physical performance testing, and salivary hormones

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000241336
Enrollment
21
Registered
2026-02-25
Start date
2026-01-08
Completion date
2026-02-27
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Primary objective To quantify pre- to post-season changes in ACL tissue properties using quantitative MRI in youth female rugby league athletes. Hypotheses 1. ACL quantitative MRI indices and morphology will demonstrate measurable changes across the season. 2. The intervention group will show greater favourable changes in ACL morphology and quantitative MRI indices compared with controls. 3. Improvements in strength/power and favourable landing/deceleration mechanics will be associated with favourable ACL MRI changes. 4. Hormonal concentrations will explain inter-individual variability in ACL MRI outcomes and adaptation, consistent with mechanobiological and endocrine influences reported in prior literature .

Interventions

Intervention: Standard Strength and Conditioning (S&C) + targeted Anterior Cruciate Ligament (ACL) loading programme. In addition to standard S&C, participants will complete an ACL-targeted programme incorporating exercises aligned with high-load knee extensor and posterior chain demands and controlled exposure to deceleration/landing/cutting patterns. The programme includes (as examples): • Nordic hamstring variations • Isometric knee-dominant strength exposures • Tibial stress/control drills •

Intervention: Standard Strength and Conditioning (S&C) + targeted Anterior Cruciate Ligament (ACL) loading programme. In addition to standard S&C, participants will complete an ACL-targeted programme incorporating exercises aligned with high-load knee extensor and posterior chain demands and controlled exposure to deceleration/landing/cutting patterns. The programme includes (as examples): • Nordic hamstring variations • Isometric knee-dominant strength exposures • Tibial stress/control drills • Progressive plyometrics and change-of-direction (COD) and resisted deceleration tasks Progression will follow planned overload (approximately 8–10% weekly progression, with deload weeks as required), with close technique supervision and workload management. Injury prevention evidence supports the importance of structured neuromuscular programmes and adherence. While Nordic hamstring evidence is strongest for hamstring injury reduction, it is included here as part of posterior chain capacity development relevant to knee loading and braking demands. The programme will be run by two University Academics with professional strength and conditioning experience. The sessions will be run as a group session i.e. 1:~20 participant ratio. Intervention will run for 15 weeks, 2 days a week (Monday and Thursday) for roughly 45 mins. Each participant will be required to complete a session attendance and weekly activity questionnaire. Participants allocation to the intervention group will be achieve by participants choice.

Sponsors

University of New England
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
8 Years to 17 Years
Healthy volunteers
Yes

Inclusion criteria

• Female rugby league athletes in the U16 pathway • Able to participate fully in squad training and testing • No prior ACL rupture/reconstruction • Parent/guardian consent and participant assent

Exclusion criteria

• Lower limb injury in prior 6 months limiting participation • Medications/conditions affecting endocrine function or growth (including hormonal contraceptives or disorders affecting sex hormone production) • MRI contraindications (e.g., non-compatible metal, severe claustrophobia)

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 14, 2026