None listed
Conditions
Brief summary
This study investigates if the addition of a molecule, platelet derived growth factor (PDGF) produced by the body in the normal healing process of a tooth extraction socket will improve the amount of bone formed. At the time of extraction a bone graft will be placed in the socket with PDGF as the test and saline as the control. Six to eight weeks later the extraction site will have an implant placed. The dimensions of the jaw will be measured clinically and radiography at the time of extraction and implant placement. In addition a bone sample will be taken to analyse the amount of new bone formed.
Interventions
This study will involve patients who require a dental extraction and subsequent dental implant placement. Their tooth will be removed as per standard protocols and the extraction site will be thoroughly cleaned, removing any infected tissue. The treating clinician will then mix a bovine and porcine derived bone grafting material with either platelet derived growth factor (0.5ml, half patient group, test) or saline (0.5ml, half of patient group, control) and placed into the extraction socket. The
This study will involve patients who require a dental extraction and subsequent dental implant placement. Their tooth will be removed as per standard protocols and the extraction site will be thoroughly cleaned, removing any infected tissue. The treating clinician will then mix a bovine and porcine derived bone grafting material with either platelet derived growth factor (0.5ml, half patient group, test) or saline (0.5ml, half of patient group, control) and placed into the extraction socket. The clinician will then place a porcine derived collagen membrane on top of the extraction socket and stitches will be placed. The procedure will add 5 minutes to the dental appointment. The treating clinician will be responsible for ensuring the application and the provision checked at regular study meetings. There is no adherence required by the subject.
Sponsors
The University of Melbourne
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Tooth requiring extraction that is suitable for replacement by a dental implant
Exclusion criteria
Untreated periodontal disease Systemic disease that affects bone healing Smoking Diabetes Pathology at the extraction Inability to place an implant at the extraction site post-extraction
Outcome results
None listed