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Caffeinated Beverages and Brain Function

Effects of Caffeinated Beverages on Cognitive Function in Healthy Adults

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000213347
Enrollment
30
Registered
2026-02-20
Start date
2022-04-04
Completion date
2022-09-30
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study compared the effects of a sucrose-based caffeinated beverage with an isomaltulose-based caffeinated beverage that also contained a small amount of l-theanine. Specifically, we examined the effects of the drinks on cognition, plasma glucose, plasma insulin, mood, and impulsivity. We hypothesised that isomaltulose would result in a lower increase in blood glucose, compared to sucrose, and that this would be reflected by a lower insulin response. Furthermore, we hypothesised that cognitive performance and subjective mood after consuming isomaltulose- l-theanine beverage would be non-inferior to the sucrose-based drink.

Interventions

Participants will consume energy drinks produced by a commercial company. Drink A is sucrose-based and contains 20 g of sucrose and 80 mg of caffeine. Drink B is isomaltulose-based and contains 20 g of isomaltulose, 80 mg of caffeine, and 10 mg of l-theanine. Each drink was 250 mL and was consumed once per session. The duration of the intervention was therefore approximately 1 day (half life of caffeine is ~11 hours). Adherence to the intervention was monitored by direct observation (drinks were

Participants will consume energy drinks produced by a commercial company. Drink A is sucrose-based and contains 20 g of sucrose and 80 mg of caffeine. Drink B is isomaltulose-based and contains 20 g of isomaltulose, 80 mg of caffeine, and 10 mg of l-theanine. Each drink was 250 mL and was consumed once per session. The duration of the intervention was therefore approximately 1 day (half life of caffeine is ~11 hours). Adherence to the intervention was monitored by direct observation (drinks were consumed in front of a researcher). The washout period between drinks was a minimum 7 days; this not only ensured any effects of caffeine and l-theanine were removed, but also any sensory effects.

Sponsors

University of Auckland
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Participants had to be over 18 years old, be willing to consume caffeine, and not be pregnant/breast-feeding

Exclusion criteria

<18 years of age, unwilling to consume caffeine, pregnant/breastfeeding

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 14, 2026