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High-intensity strength training for people with Parkinson’s disease to test safety and feasibility (HiSTEP-PD pilot trial)

High-intensity Strength Training Exercise Program for People with Parkinson’s Disease (HiSTEP-PD): a Phase 1 Safety and Feasibility Pilot Trial

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12626000205336
Enrollment
10
Registered
2026-02-19
Start date
2026-03-09
Completion date
2026-10-12
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will test whether a supervised high-intensity strength training program is safe, practical, and acceptable for people living with mild-to-moderate Parkinson’s disease. Participants will complete a structured gym-based strength training program over approximately 8 weeks, with testing before and after the program. The study will monitor safety (including any adverse events), recruitment and attendance, and changes in physical function, mobility, balance, strength, brain health and quality of life. Some participants and trainers will also be interviewed about their experience. We hypothesise that high-intensity strength training will be safe and feasible to deliver in this population, and may lead to improvements in strength and physical function.

Interventions

Twice-weekly high-intensity progressive resistance training sessions are delivered over 8 weeks in a gym setting for community-dwelling people with Parkinson’s disease. Each session will be 1hr in length and is provided on a one-to-one basis, with a participant paired with a Masters-level student trainer (physiotherapy, osteopathy, or exercise physiology) who has completed a structured train-the-trainer workshop and competency process. All sessions occur under direct on-site supervision from qua

Twice-weekly high-intensity progressive resistance training sessions are delivered over 8 weeks in a gym setting for community-dwelling people with Parkinson’s disease. Each session will be 1hr in length and is provided on a one-to-one basis, with a participant paired with a Masters-level student trainer (physiotherapy, osteopathy, or exercise physiology) who has completed a structured train-the-trainer workshop and competency process. All sessions occur under direct on-site supervision from qualified allied health clinical staff. Training intensity will be monitored using rating of perceived exertion (RPE), with working sets typically targeting RPE 7–8/10, alongside structured programming (generally 2–3 sets of 6–8 repetitions with 2–3 minutes rest). Load prescription is informed by 3-repetition maximum (3RM) testing for key exercises (e.g., leg press, chest press) at baseline and post-intervention, with loads progressed conservatively based on technique, symptoms, and safety. Attendance and adherence will be recorded at every session using structured trainer logs documenting session completion, loads, RPE, and any symptoms. Prior to each session, participants are screened for fatigue, soreness, and symptom changes, and any adverse events are documented and managed according to study procedures. Exercises target major muscle groups using machine-based and/or free-weight movements tailored to individual capacity and may include leg press, chest press, knee extension/flexion, rowing or pull-down variations, hip hinge movements, and hip abduction. Sessions will include a light aerobic and mobility warm-up, a progressive resistance training block, and a cool-down involving stretching or breathing exercises.

Sponsors

Victoria University
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

A confirmed diagnosis of Parkinson’s disease, present with mild-to-moderate motor disability (Hoehn and Yahr stage I–III), are aged 18–80 years, and are able to understand English and follow instructions to safely complete the training, testing and study

Exclusion criteria

Individuals will be excluded if they are unable to safely participate in high-intensity strength training due to medical contraindications, or are unable to complete the required assessments and study procedures. Participants will also be excluded where significant comorbidities or impairments would limit safe exercise participation or the valid completion of testing. Examples include orthostatic hypotension; clinically relevant cardiovascular conditions; respiratory/lung conditions; musculoskeletal conditions (e.g., back pain or arthritis) or current injury; uncontrolled diabetes; mood or psychiatric disorders; chronic fatigue syndrome; cognitive dysfunction; unmanaged medical or surgical conditions; severe auditory or visual impairment; cancer; obesity; bone disease; or if currently receiving deep brain stimulation or using Parkinson’s medication infusion/pump systems.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 14, 2026