Critical Illness, Infection and Immunology Biobank

CI3 Biobank is an open biospecimen repository (biobank) created to facilitate future translational research into conditions such as sepsis, including but not limited to cellular, molecular, transcriptomic, proteomic, metabolomic and genomic projects. Potential participants will be those presenting to the participating institution/s with an infection, inflammation, or immune dysfunction-related diagnosis. Participants will be patients admitted to Intensive Care Unit. They will be separated into 3 groups based on the reason of admission to ICU. Patients with diagnosis or clinical suspicion of sepsis will be categorised to Group A and participants with any non-infective inflammation will be categorized to Group B participants. Both groups will need to have Sequential Organ Failure Assessment (SOFA) > or = 2 (SOFA score greater than or equal to 2) to be eligible for biobank inclusion. Group C is the third category of participants who will have neither any infection nor any inflammation, with SOFA score of 2 or less than 2. Potential participants will be invited directly (or through their Person Responsible) to take part in the Biobank. Consented participants will be enrolled in the Biobank by contributing their biospecimens including blood, urine, cerebrospinal fluid, bronchoalveolar lavage, stool, and tissue samples to biobank. Blood samples will be collected at 5 timepoints: Baseline, day 3, 1 month, 6 months and 12 months from ICU admission. WHODAS questionnaire will be completed by participants at 6 and 12 months. Biospecimens will be de-identified and stored securely for future studies relating to the risk factors, diagnosis, response to treatment and outcomes of inflammation driven critical illnesses. Participation into CI3 Biobank entails blood collection and completing a Health and Disability outcome using World Health Organization Disability Assessment Schedule (WHODAS) 2.0 questionnaire. Blood collection will occur at Baseline, day 3, 1 month, 6 months and 12 months from recruitment. WHODAS questionnaire will be due at 6- and 12-months post enrolment. Participants will have the option to opt out of any these milestones at any point. Participants will be categorised into 3 groups. Group A and B participants will be Admitted to Intensive Care Unit with diagnosis of infection (Group A) and non-infective inflammation (Group B) both with Sequential Organ Failure Assessment (SOFA) = 2 (greater than or equal to 2) . Group C participants are healthy (no infection and inflammation) participants with SOFA score </= 2 (less than or equal to 2) who may be in ICU or healthy volunteers.