None listed
Conditions
Brief summary
This study aims to investigate whether a cream containing Queen Garnet Plum Extract can help reduce the severity of symptoms in people with mild to moderate atopic dermatitis (eczema). Atopic dermatitis is a common inflammatory skin condition characterised by itching, redness, and dry skin. The study hypothesises that regular topical application of a Queen Garnet Plum Extract-containing cream over 12 weeks may improve skin condition and reduce disease severity compared to a placebo cream without the active extract.
Interventions
Participants will be randomised to receive either a Queen Garnet Plum Extract-containing cream or a placebo cream identical in appearance but without the active extract. Participants will be instructed to apply the assigned cream twice daily to affected areas of skin for a 12-week intervention period.
The dosage will be standardised using the fingertip unit (FTU) method, with approximately one fingertip unit applied per palm-sized area of affected skin per application.
Adherence to the intervent
Participants will be randomised to receive either a Queen Garnet Plum Extract-containing cream or a placebo cream identical in appearance but without the active extract. Participants will be instructed to apply the assigned cream twice daily to affected areas of skin for a 12-week intervention period. The dosage will be standardised using the fingertip unit (FTU) method, with approximately one fingertip unit applied per palm-sized area of affected skin per application. Adherence to the intervention will be monitored using a mobile application, through which participants will record twice-daily cream use, report weekly eczema symptoms, and express their perceived control over their skin condition as reflected by its impact on quality of life.
Sponsors
Victoria University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Adults aged between 18-45 years; Clinical diagnosis of mild to moderate atopic dermatitis (eczema) Presence of active eczema lesions suitable for topical treatment and assessment Willingness to apply the assigned topical cream twice daily for 12 weeks Ability to comply with study procedures, including clinical assessments and weekly symptom reporting (POEM and RECAP) via a digital app Ability to provide written informed consent
Exclusion criteria
Severe atopic dermatitis as defined by SCORAD Use of systemic immunosuppressive or biologic therapy for atopic dermatitis Presence of other active skin conditions that may interfere with assessment Allergic to any component of the investigational or placebo cream Pregnant or breastfeeding individuals Initiation or change of any eczema-related medication prior to baseline or during the study period
Outcome results
None listed