None listed
Conditions
Brief summary
This prospective, randomized, double-blind, contolled trial will evaluate the effect of adding dexmedetomidine to 0.375% ropivacaine in the posterior quadratus lumborum block (QLB2) on postoperative opioid requirements in patients undergoing laparoscopic colorectal surgery. Sixty patients will be randomly assigned to recieve either ropivacaine alone or ropivacaine with dexmedetomidine. The primary outcome is total opioid requirement within the first 24 hours after surgery, while secundary outcomes include time to first rescue analgesia, sedation levels and hemodynamic stability. It is hypothesized that the addition of dexmedetomidine will prolong analgesia and reduce postoperative opioid use compared with ropivacaine alone.
Interventions
Participants will receive a bilateral posterior quadratus lumborum block performed under ultrasound guidance prior to a single scheduled surgical procedure, in accordance with current technical and safety recommendations for regional anesthesia. The block will be administered using 0.375% ropivacaine, 20 ml per side, not exceeding the maximum safe dose of 3 mg/kg, combined with dexmedetomidine at a dose of 1 mcg/kg, up to a maximum safe dose of 100 mcg. The intervention is administered once, imm
Participants will receive a bilateral posterior quadratus lumborum block performed under ultrasound guidance prior to a single scheduled surgical procedure, in accordance with current technical and safety recommendations for regional anesthesia. The block will be administered using 0.375% ropivacaine, 20 ml per side, not exceeding the maximum safe dose of 3 mg/kg, combined with dexmedetomidine at a dose of 1 mcg/kg, up to a maximum safe dose of 100 mcg. The intervention is administered once, immediately before surgery, with no repeat dosing. Adherence to the intervention protocol will be ensured and documented through anesthesia records, including drug type, concentration, volume, total dose and timing of administration. Participants will be monitored perioperatively and postoperatively for analgesic efficacy, additional analgesic requirements, hemodynamic parameters and adverse events, with all data recorded in the patient's medical records.
Sponsors
Klinicki bolnicki centar Sestre milosrdnice
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients classified as ASA II-III, scheduled for elective laparoscopic colorectal surgery and who have provided written informed consent.
Exclusion criteria
Patients with psychiatric disorders or cognitive impariment, opioid dependance, chronic analgesic use, known allergy to study medications, coagulation disorders, hepatic or renal insufficiency
Outcome results
None listed