None listed
Conditions
Brief summary
The primary objective is to compare between tight and moderate glycemic control in reducing the rate of surgical site infection, determine the ideal range of glucose control to minimize surgical site infection and evaluate factors associated with SSI in post CABG patients. We Hypotheses that tight glycemic control reduces the rate of surgical site infection. The outcome will be reduced rate of SSI at 30 days post-surgery. Data will be analyzed using intention to treat analysis
Interventions
For the intervention - tight glycemic control
This involved maintaining blood glucose levels(BGL) at 'target range' of 4.4mmol/L–6.0 mmol/L. The registered nurses(RN) cum diabetic educator will monitored the BGL in order to stabilizes within target range for two consecutive hour. if the BGL exceeds the upper limit or trends lower than desired, the RN will adjust accordingly. For example, if BGL goes below 4.4mmol/L, with rapid infusion halts if hypoglycemia (BGL <4.0 mmol/L) occurs. The mode
For the intervention - tight glycemic control This involved maintaining blood glucose levels(BGL) at 'target range' of 4.4mmol/L–6.0 mmol/L. The registered nurses(RN) cum diabetic educator will monitored the BGL in order to stabilizes within target range for two consecutive hour. if the BGL exceeds the upper limit or trends lower than desired, the RN will adjust accordingly. For example, if BGL goes below 4.4mmol/L, with rapid infusion halts if hypoglycemia (BGL <4.0 mmol/L) occurs. The mode of delivery will be insulin infusion through Intravenous (IV) line and delivered by registered nurse who will be monitoring the frequency/duration of the intervention monitoring prior to surgery and post-operatively every one to 2 hours in the cardiac critical care and recovery wards
Sponsors
Sarawak Consolidated Industries
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Elective Coronary Artery Bypass Graft (CABG) • Type 2 Diabetic • Able to provide informed consent. • Adults over the age of 18
Exclusion criteria
1. Presence of active auto-immune or immune diseases and patients with the use of systemic steroid or immunosuppresant 2. type 1 diabetic, gestational diabetes 3. patient undergoing valve replacement surgery
Outcome results
None listed