None listed
Conditions
Brief summary
In this study the efficacy of intralesional Vitamin D3 was compared with cryotherapy in cutaneous warts. Total 68 patients allocated equally in two groups. Group A will be given intralesional vitamin D3 and group B will be treated with cryotherapy. Efficacy will be assessed through clinical examination to look for complete clearance. Purpose of the study is that there is difference in the efficacy of intralesional vitamin D3 vs cryotherapy.
Interventions
Intralesional administration of vitamin D3 stimulates expression of vitamin D receptors, leading to synthesis of antimicrobial peptides and cytokines.This process helps to control cellular growth and specialization. This immunomodulatory properties of vitamin D3 therapy enhance the body's innate ability to combat HPV infection.
Treatment protocol: treatment will be delivered by registered nurse, using the following steps
1. Alcohol wipes are used as a disinfectant to clean the surface of the cu
Intralesional administration of vitamin D3 stimulates expression of vitamin D receptors, leading to synthesis of antimicrobial peptides and cytokines.This process helps to control cellular growth and specialization. This immunomodulatory properties of vitamin D3 therapy enhance the body's innate ability to combat HPV infection. Treatment protocol: treatment will be delivered by registered nurse, using the following steps 1. Alcohol wipes are used as a disinfectant to clean the surface of the cutaneous wart and surrounding skin to be treated. 2. Local anaesthetic is administered; either local infiltration (0.2ml of xylocaine plain 2% (20mg/ml) injected via 30-gauge needle using insulin syringe at the base of the wart) or block technique depending on the location and size and number of the wart. 3. 5 minutes after injecting local anaesthesia, 0.6ml of vitamin D3 200000 IU (Inj. Indrop-D 5mg/5ml) infiltrated into the base of warts using 30-gauge needle (insulin syringe). 4. Maximum of 4 warts per session will be injected at the base of warts every 2 weeks for the duration of 10 weeks. 5. Efficacy will be defined as ability of intralesional vitamin D3 to result in complete clearance through clinical examination after 10 weeks of administering treatment. Adherence to Intervention will be assessed by calling the patient for follow up every 2 weeks and looking for the response of treatment assessing the numbers and size of warts.
Sponsors
Associate Professor Dr Irfanullah Afridi, Dermatology department, KHYBER TEACHING HOSPITAL ,PESHAWAR
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Patients diagnosed with cutaneous warts, on the basis of clinical examination showing all of the following characteristics such as small, rough, raised lesions on the skin, often with cauliflower-like texture which may cause pain.
Exclusion criteria
- Patients suffering from bleeding disorder - Patients with superadded infection - Pregnant/lactating mothers - Patients with erythema around the warts
Outcome results
None listed