None listed
Conditions
Brief summary
The Menopausal transition is linked with reduced physical activity and mood disturbances. Microbiome-targeted therapies such as oral Lactobacillus may influence motivation and exercise via the gut-brain axis.
Interventions
Intervention:
Lactobacillus. paracasei Lpc-37®, 8.75 billion CFU twice daily
Lactobacillus plantarum (299v) 10 billion CFU twice daily
Duration: 6 weeks
Administration: Oral capsule
Monitor adhereance: daily surveys collecting self-reported data for motivation (IMI, SRQ-E), Gastrointestinal sx (GSRS), psychological well-being (GHQ-12), muscle soreness(VAS), menopause sx, exercise activity.
Baseline 25/8/25 to 5/9/25
Intervention 6/9/25 to 17/10/25
Sponsors
Southern Cross University
Study design
Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
40 Years to 54 Years
Healthy volunteers
Yes
Inclusion criteria
Female aged 40 to 54. Lives in Adelaide, South Australia, Australia. Has access to the internet and email, with availability to complete a daily 3-5-minute online survey for the duration of the 8-week trial period. Currently engaging in resistance exercise or brisk walking, at least twice per week. Experiencing at least one, or a combination of, peri/menopausal symptoms such as hot flushes, joint pain and stiffness, vaginal dryness, night sweats, and urinary incontinence (e.g., during laughter or exercise). Participants’ average daily diet must include at least three meals per day, with no highly restrictive diet regimes (e.g., Keto, carnivore, or low-fibre).
Exclusion criteria
Currently taking antibiotics or hormone replacement therapy. Has existing or active medically diagnosed gastrointestinal disease such as ulcerative colitis, Crohn's disease, or diverticulitis. Medically diagnosed with hypertension. History of anaphylactic episodes, or severe allergic reactions.
Outcome results
None listed